HLA genes in Type 2 diabetes: Protection and risk

Le résumé fourni par la source

housands of genes in our cells code for proteins that orchestrate an array of biological functions.Their complex interplay along with environmental factors determine health and disease.Advanced genotyping technologies enable extensive genome sequencing -this means that the combination of DNA pairs making up genetic information can be analysed to better understand the pathology of disease.Using such techniques, including computer algorithms, are researchers in the genetics section of the NIH Intramural Branch in Phoenix, Arizona whose work focuses on human genetic variations and the risk of Type 2 diabetes (T2D) in Indigenous Americans.Professor Robert C Williams and his team conducted a recent study which suggests a genetic phenomenon between two genes that confers protection against T2D in overweight, not lean individuals.Such unexpected, intriguing results warrant further investigation.

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