Chemical Profiling and Cytotoxicity Activity of Essential Oil from Artemisia Maritima Collected through Four Different Wild Locations of Lahaul Valley in Indian Western Himalaya

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Abstract This research leads to the analysis of quality parameters and chemical profiles of Artemisia maritima essential oils (EOs) extracted from four different wild areas viz: Darcha, Jispa, Gemur and Tandi of Lahaul valley of Indian western Himalaya in comparison to a market sample. The EOs content was found higher in Darcha (0.54 %) and Jispa (0.48 %). The quality parameters such as color, odor, density, refractive index and optical rotations were found comparable with the market sample. Further, volatile chemo‐profile of EOs was generated using GC/GC‐MS. A total of 34 metabolites were identified in five samples (n=3) that account around 87.3–95.1 % of the total oils. These EOs majorly contained monoterpene hydrocarbons (3.0–68.5 %) and oxygenated monoterpenes (26.6–85.0 %) with β‐myrcene (9.8–20.6 %), α‐terpinene (0.7–17.3 %), β‐phellandrene (1.5–22.4 %), 1,8‐cineole (3.0–50.8 %), terpinen‐4‐ol (2.5–7.2 %), ascaridole (11.5 %), bornyl acetate (5.1–14.2 %), trans‐sabinyl acetate (0.8–49.6) and trans‐ascaridole (7.9 %). Moreover, cytotoxicity study of EOs against CaCo2 and HT‐29 human colon carcinoma cell lines unveiled significant anticancer potential of A. maritima. AMD (82.87±0.39 %) AMG (61.17±1.45 %) and AMM (73.37±2.1 %) showed comparable activity at 600 μg/ml (72 hr) in comparisons to vinblastine (20 μM). A. maritima is less explored as compared to other species and could be a new potential source for EOs and anticancer candidate.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.