Nutritional Ketosis as a Therapeutic Approach in Critical Illness: A Systematic Review
Rattachement africain : jo, us, bh, in. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Critical illness encompasses the dysfunction of vital organs, the risk of death, and potential reversibility; it is a major cause of morbidity and mortality globally. The pathophysiology underlying many critical illnesses includes bioenergetic failure, inflammation, and oxidative stress. This systematic review aims to explore the use of nutritional ketosis (ketogenic feeds and exogenous ketone body administration) as a potential therapy, affecting the aforementioned pathways in patients with critical illnesses. This study was conducted, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The search was conducted, systematically using PubMed, PubMed Central (PMC), Google Scholar, and the ScienceDirect databases in February 2024. The inclusion criteria were set to free full-text articles published within the past five years: human and animal studies, literature reviews, systematic reviews, meta-analyses, observational studies, randomized controlled trials, case reports, book chapters, gray literature, studies investigating adult samples, and articles in the English language. Exclusion criteria included pediatric studies as the topic has been studied more extensively in children, and this review aims to explore potential benefits in adult patients. The search was conducted through four databases; after the screening process, the remaining studies were assessed through quality appraisal tools appropriate to each study type. In the end, 11 studies were selected, including eight narrative reviews, one cohort study, one animal study, and one randomized controlled trial. The results of this review demonstrated that nutritional ketosis has potential safe and effective benefits for humans and animals. Nutritional ketosis shows therapeutic benefits for a vast variety of complications commonly associated with critical illness, status epilepticus, sepsis, viral infections, and glycemic control. In the end, both randomized and nonrandomized clinical trials are necessary for more conclusive findings.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Nutritional Ketosis as a Therapeutic Approach in Critical Illness: A Systematic Review
- Date Crossref
- 26/07/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Jordan pays non établi dans la noticeUniversité ou école supérieure
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University of North Texas . Department of Pediatrics and Women's Health pays non établi dans la noticeUniversité ou école supérieure
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Mayo Clinic . Gastroenterology and Hepatology pays non établi dans la noticeÉtablissement de santé
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Applied Science Private University pays non établi dans la noticeUniversité ou école supérieure
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University of North Texas Health Science Center pays non établi dans la noticeUniversité ou école supérieure
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Royal College of Surgeons in Ireland - Bahrain Medicine pays non établi dans la noticeUniversité ou école supérieure
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California Institute of Behavioral Neurosciences and Psychology (United States) . Dermatology pays non établi dans la noticeEntreprise
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All India Institute of Medical Sciences Bhubaneswar . Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Mayo Clinic in Arizona pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic in Florida pays non établi dans la noticeÉtablissement de santé
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Armed Forces Medical College pays non établi dans la noticeUniversité ou école supérieure
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Jordan University of Science and Technology . Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
University of Jordan, . Department of Pediatrics and Women's Health — University of North Texas et . Gastroenterology and Hepatology — Mayo Clinic, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.