Editorial: Immune dysfunction in acute pancreatitis: from bench to bedside research
Rattachement africain : cn, it, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Immune dysfunction in acute pancreatitis: from bench to bedside researchAcute pancreatitis is an common inflammatory gastrointestinal disease requiring acute admission to hospital (1).Most patients with acute pancreatitis have mild and self-limited symptoms, while up to 20% of patients develop severe disease requiring intensive care monitoring and support for organ failure (2).The incidence of AP is increasing at a rate of 2%-5% per year and varies between 3.4 and 73.4 cases per 100,000 worldwide (3).Despite the global burden of disease, there are currently no effective therapeutic agents to treat or prevent acute pancreatitis (4).Research into the pathogenesis of acute pancreatitis may help to identify novel cellular targets for potential drug development.There is increasing evidence that the severity and prognosis of acute pancreatitis are associated with uncontrolled or deregulated immune-system activation (4).This Research Topic highlights advances in the understanding of immune dysfunction in acute pancreatitis.Normal gut mucosa is normally an effective barrier against the spread of toxins.Ischaemia and reperfusion of the intestinal mucosa during acute pancreatitis may damage the integrity of the intestinal barrier and increase intestinal permeability (5).The increased intestinal permeability could then lead to translocation of enteric bacteria and/or fungi into the pancreas, further contributing to the development of pancreatic necrosis and multiple organ failure.Reportedly, 68.8% of patients suffering from acute pancreatitis have bacterial DNA in their peripheral blood and over half (60.4%) display polymicrobial flora (6).Innate and adaptive immune cells stimulated by both pathogens and damage-associated molecular patterns (DAMPs) via pattern recognition receptors (PRRs) which including toll-like receptor-4 (TLR4) and dectin-1 (7), and the non-PRR DAMP receptors may be involved in amplifying proinflammatory cytokine responses and severe tissue injury (8).A mini-review
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Editorial: Immune dysfunction in acute pancreatitis: from bench to bedside research
- Date Crossref
- 19/07/2024
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wenzhou Medical University Department of Gastroenterology and Hepatology pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Wenzhou Medical University pays non établi dans la noticeÉtablissement de santé
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Ospedale Sandro Pertini pays non établi dans la noticeÉtablissement de santé
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Harbin Medical University Department of Pancreatic and Biliary Surgery pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Harbin Medical University pays non établi dans la noticeÉtablissement de santé
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Zhejiang University pays non établi dans la noticeUniversité ou école supérieure
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Nanchang University Department of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Nanchang University pays non établi dans la noticeÉtablissement de santé
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The University of Texas Health Science Center at Houston pays non établi dans la noticeUniversité ou école supérieure
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Sandro Pertini Hospital Unit of Gastroenterology and Digestive Endoscopy pays non établi dans la noticeÉtablissement de santé
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School of Medicine Department of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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University of Texas Health Sciences Center Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
Department of Gastroenterology and Hepatology — Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University et Ospedale Sandro Pertini, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.