Neuroaxonal Injury May Mediate the Association Between Hyperglycemia and Prognosis in Spontaneous Subarachnoid Hemorrhage
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Le résumé fourni par la source
Hyperglycemia during early brain injury (EBI) period after spontaneous subarachnoid hemorrhage (SAH) is associated with poor outcome, but the underlying physiopathology is unknown. This study assessed if hyperglycemia during EBI is associated with markers of neuroaxonal injury and whether these biomarkers partially account for the association between hyperglycemia and poor clinical outcome. Ninety-two SAH patients admitted within 24 h of bleeding onset were prospectively included. Glucose levels were measured at arrival and every 6 h for 72 h. Serum neurofilament light chain (NFL) levels were measured at 72 h. Functional outcome was assessed with the modified Rankin Scale (mRS) at 90 days (poor outcome, mRS > 2). The association between glucose metrics, NFL levels, and clinical outcome was assessed with univariate and multivariate analyses. Mediation analysis was performed to examine the potential chain in which NFL may mediate the relationship between glucose and functional outcome. Higher glucose and NFL levels during EBI were associated with poor clinical outcome in adjusted analysis. NFL levels were associated with older age, higher initial severity, and higher glucose levels during EBI period. In adjusted mediation analyses, the association between glucose and clinical outcome was significantly mediated by NFL levels. The mediator NFL explained 25% of the association between glucose during EBI period and poor functional outcome at 90 days. In SAH, the association between glucose levels during EBI and poor clinical outcome might be significantly mediated by NFL levels. The link between hyperglycemia and poor clinical outcome might be explained in part through secondary neuroaxonal injury.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neuroaxonal Injury May Mediate the Association Between Hyperglycemia and Prognosis in Spontaneous Subarachnoid Hemorrhage
- Date Crossref
- 12/07/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Neurosciences Institute pays non établi dans la noticeOrganisation à but non lucratif
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Universitat de Barcelona pays non établi dans la noticeUniversité ou école supérieure
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Hospital Clínic de Barcelona pays non établi dans la noticeÉtablissement de santé
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Consorci Institut D'Investigacions Biomediques August Pi I Sunyer pays non établi dans la noticeStructure de recherche
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Ikerbasque pays non établi dans la noticeInstitution
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Achucarro Basque Center for Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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Consejo Superior de Investigaciones Científicas pays non établi dans la noticeOrganisme public
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Institut d'Investigacions Biomèdiques de Barcelona pays non établi dans la noticeStructure de recherche
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University of Barcelona Institute of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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Institute of Neuroscience pays non établi dans la noticeStructure de recherche
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Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer (IDIBAPS) pays non établi dans la noticeStructure de recherche
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Hospital Clinic of Barcelona Anesthesiology Department pays non établi dans la noticeÉtablissement de santé
Neurosciences Institute, Universitat de Barcelona et Hospital Clínic de Barcelona, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.