Accès ouvert déclaré
2024
article
High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19
Robin L. Goossen, Relin van Vliet, Lieuwe D. J. Bos, Laura A. Buiteman‐Kruizinga, Markus W Hollman, Sheila Nainan Myatra, Ary Serpa Neto, Peter E. Spronk, Meta C. E. van der Woude, David M. P. van Meenen, Frederique Paulus, Marcus J. Schultz, Sanchit Ahuja, J.P. van Akkeren, Anna Geke Algera, C.K. Algoe, Rombout B. E. van Amstel, Antonio Artigas, Eda Aydeniz, Melanie J. Bailey, A.E. van den Berg, P. van de Berg, D. C. J. J. Bergmans, D.I. van den Bersselaar, F.A. Bertens, Melissa S. A. M. Bevers, Alexander J. G. H. Bindels, Jennifer S. Breel, Sanne de Bruin, C.L. Bruna, M. de Boer, Dirk P. Boer, Sylvia den Boer, L.S. Boers, Margriet Bogerd, Brigitte Bosman, Michela Botta, O Baur, W. Coene, Olaf L. Cremer, Kathleen L.J. Daenen, M. Delmte, R.M. Determann, Willem Dieperink, V. Di Leo, J. van Dijk, Dave A. Dongelmans, Tom Dormans, Hendrik Endeman, L. Elting, Andrea A. Esmeijer, Davide Filippini, J.M. Flim, H.S. Franke, Michał S. Gałek-Aldridge, M.G. Gama de Abreu, Armand R. J. Girbes, Dean Go, Mart J. de Graaff, Laura A. Hagens, Hans Jørgen Hansen, Jasper J. Haringman, S.T. van der Heide, Pim L. J. van der Heiden, Nanon F. L. Heijnen, S.J.P. Hiel, Lotte Hoeijmakers, Liselotte Hol, Markus W. Hollmann, Marga Hoogendoorn, Janneke Horn, I. van der Horst, R. van der Horst, Jilske Huijben, E.L.K. Ie, L.E. van Ingen, D.P. Ivanov, Nicole P. Juffermans, Hetty Kranen, Eline Kho, Eline S. de Klerk, N. Koek, A.W.M.M. Koopman-van Gemert, Matty Koopmans, Songul Kucukcelebi, Michaël Kuiper, L. Kuipers, Eline Koornstra, A. Lokhorst, Dylan W. de Lange, Ignacio Martín‐Loeches, David M. P. van Meenen, Guido Mazzinari, H. Moeniralam, Niels van Mourik, Sunny G. L. H. Nijbroek, P. van Oosten, M. Offermans, Marisa Onrust, Evelien Oostdijk, Frederique Paulus, C.J. Pennartz, Jasminka Peršec, Vincent Peters, Janesh Pillay, Luigi Pisani, T. Pisters, A. Prins, Ilse M. Purmer, Thijs C. D. Rettig, A.S. Rezaee, Oriol Roca, J. Roozeman, J. Rozendaal, Nahum Rosenberg, R. Schavemaker, Alba Sciascera, M.T.U. Schuijt, M.J. Schultz, Ary Serpa Neto, Gentle Sunder Shrestha, Bart van Silfhout, Michael W. Sjoding, M. E. Sleeswijk, K.M. van Smaalen, Marry R. Smit, Andrej Šribar, Aart C. Strang, Willemke Stilma, P. Swart, Pieter R. Tuinman, Anissa M. Tsonas, Corstiaan A. den Uil, Christel M. A. Valk, F.L. Veen-Schra, A.P.J. Vlaar, Lars I. Veldhuis, Ward H. van der Ven, Fleur–Stefanie L. I. M. van der Ven, Patricia van Velzen, Murielle Verboom, E.J. Verhoef, Tyler D. Vermeulen, Jaco Voorham, Peter H. J. van der Voort, L. van Welie, Daniel L. Weller, A.R. Wentink, H.J.F.T. Wesselink, H. van der Wier-Lubbers, B. van Wijk, Hugo D.G. van Willigen, Margaretha C. E. van der Woude, J.J. Weiner, Tineke Winters, Wing-Yen Wong, N. Yaali, J.M. Zandvliet, Arthur R. H. van Zanten, T.Z.I. van Zijl, Svenja Zonneveld
3Citations signalées — pas une note de qualité
15Institutions déclarées
7Pays d’affiliation déclarés
Résumé fourni par la source
The positive end–expiratory pressure (PEEP) strategy in patients with coronavirus 2019 (COVID–19) acute respiratory distress syndrome (ARDS) remains debated. Most studies originate from the initial waves of the pandemic. Here we aimed to assess the impact of high PEEP/low FiO2 ventilation on outcomes during the second wave in the Netherlands. Retrospective observational study of invasively ventilated COVID–19 patients during the second wave. Patients were categorized based on whether they received high PEEP or low PEEP ventilation according to the ARDS Network tables. The primary outcome was ICU mortality, and secondary outcomes included hospital and 90–day mortality, duration of ventilation and length of stay, and the occurrence of kidney injury. Propensity matching was performed to correct for factors with a known relationship to ICU mortality. This analysis included 790 COVID–ARDS patients. At ICU discharge, 32 (22.5%) out of 142 high PEEP patients and 254 (39.2%) out of 848 low PEEP patients had died (HR 0.66 [0.46–0.96]; P = 0.03). High PEEP was linked to improved secondary outcomes. Matched analysis did not change findings. High PEEP ventilation was associated with improved ICU survival in patients with COVID–ARDS.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19
- Date Crossref
- 01/10/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Respiratory Support and MechanismsSepsis Diagnosis and TreatmentCOVID-19 Clinical Research Studies