O-024 OCCUPATIONAL DIESEL EXHAUST EXPOSURE AND CORONARY ARTERY CALCIFICATION

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Abstract Introduction Coronary artery calcification is a major feature of ischaemic heart disease. Occupational exposure to diesel exhaust has been related to increased risk of ischaemic heart disease. We examined if coronary artery calcification was associated with occupational exposure to diesel exhaust. Methods Lifetime occupational exposure was assessed by a quantitative job exposure matrix based on a quantitative job exposure matrix. Associations between cumulative diesel exhaust exposure (µg/m3-years) and coronary artery calcification score (none=0; low=1-100; moderate=101-400; severe≥401) were analysed with ordered logistic regression among patients with a cardiac CT scan between 2005-2018. Analyses were stratified by sex and adjusted for age (2-year intervals), household income, employment status, probability of smoking and BMI, cohabitation and relevant medications. Results Preliminary results show a total of 19,861 patients were included. No coronary artery calcification was detected in 39 % of the participants, whereas 13 % had a score ≥ 401. Increasing cumulative diesel exhaust exposure did not seem to be associated with an increasing risk of coronary artery calcification, OR 1.00(0.97-1.03) p=0.994 for men and OR 1.04(0.98-1.10) p=0.211 for women in the fully adjusted model. Discussion and Conclusion These cross-sectional findings do not suggest that occupational diesel exhaust exposure contributes to ischaemic heart disease through coronary artery calcification.

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