Evaluating virulence features of Acinetobacter baumannii resistant to polymyxin B
Rattachement africain : br. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The increasing resistance to polymyxins in Acinetobacter baumannii has made it even more urgent to develop new treatments. Anti-virulence compounds have been researched as a new solution. Here, we evaluated the modification of virulence features of A. baumannii after acquiring resistance to polymyxin B. The results showed lineages attaining unstable resistance to polymyxin B, except for Ab7 (A. baumannii polymyxin B resistant lineage), which showed stable resistance without an associated fitness cost. Analysis of virulence by a murine sepsis model indicated diminished virulence in Ab7 (A. baumannii polymyxin B resistant lineage) compared with Ab0 (A. baumannii polymyxin B susceptible lineage). Similarly, downregulation of virulence genes was observed by qPCR at 1 and 3 h of growth. However, an increase in bauE, abaI, and pgAB expression was observed after 6 h of growth. Comparison analysis of Ab0, Ab7, and Pseudomonas aeruginosa suggested no biofilm formation by Ab7. In general, although a decrease in virulence was observed in Ab7 when compared with Ab0, some virulence feature that enables infection could be maintained. In light of this, virulence genes bauE, abaI, and pgAB showed a potential relevance in the maintenance of virulence in polymyxin B-resistant strains, making them promising anti-virulence targets.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Evaluating virulence features of <i>Acinetobacter baumannii</i> resistant to polymyxin B
- Date Crossref
- 28/06/2024
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Universidade Católica de Brasília Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia pays non établi dans la noticeUniversité ou école supérieure
-
Universidade Católica Dom Bosco Programa de Pós-Graduação em Biotecnologia pays non établi dans la noticeUniversité ou école supérieure
-
Universidade de Brasília Programa de Pós-Graduação em Patologia Molecular pays non établi dans la noticeUniversité ou école supérieure
-
Microbiology Department pays non établi dans la noticeInstitution
Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia — Universidade Católica de Brasília, Programa de Pós-Graduação em Biotecnologia — Universidade Católica Dom Bosco et Programa de Pós-Graduação em Patologia Molecular — Universidade de Brasília, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.