Accès ouvert déclaré
2024
article
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study
Christine L. Clarke, Hoda Anton‐Culver, Marike Gabrielson, Hakan Lars Olsson, Jennifer L. Stone, Manuela Gago-Domínguez, U. Hamann, John Llewelyn Hopper, Mary Beth Terry, Anthony J. Swerdlow, Michelle Harvie, Dijana Plaseska-Karanfilska, Kristan J. Aronson, Thomas U. Ahearn, Terry J. Boyle, Arto Mannermaa, Marina Bermisheva, Christoph Engel, Vessela Nedelcheva Kristensen, Joe Dennis, Jonathan Lacey, Nicola J. Camp, Rachel A. Murphy, Harald Surowy, David John Hunter, Päivi Auvinen, L. Le Marchand, José Á. García-Sáenz, Barbara Wappenschmidt, Thilo Dörk, Lothar Häberle, Jack A. Taylor, Erika Rees‐Punia, Ines Nevelsteen, Christopher J. Scott, S.J. Chanock, Laura E. Beane Freeman, Thérèse Truong, Masood Manoochehri, F.J. Couch, Bernardo Bonanni, Argyrios Ziogas, MJ Hooning, Hedy S. Rennert, Stella Koutros, Roger Laughlin Milne, Niclas Håkansson, Kyriaki Michailidou, Melanie Gündert, M.B. Daly, Nadège Presneau, Nataliia Bogdanova, Montserrat García‐Closas, Volker Arndt, Steven N. Hart, Marı́a Elena Martı́nez, CARL P. BLOMQVIST, P.D.P. Pharoah, Celine M. Vachon, Federico Canzian, Antoinette Hollestelle, Richard Michael Martin, Hermann Brenner, Alpa V Patel, Sibylle Loibl, Anthony Howell, Drakoulis Yannoukakos, Allison W. Kurian, P. Devilee, Christine B. Ambrosone, Suzanne C. Dixon‐Suen, Atocha Romero, Lin Fritschi, Angela Cox, Katerina Kubelka‐Sabit, A. Lindblom, A. Wolk, Sara J Lewis, Anna Jakubowska, M.A. Troester, Pascal Guénel, Clarice Ring Weinberg, D. Mavroudis, Jan Lubiński, Peter Andreas Fasching, G. Rennert, D.F. Easton, Dominic Conroy, Miriam Victoria Dwek, Jacques Simard, Simon S. Cross, Heiko Becher, A. Heather Eliassen, Robert A.E.M. Tollenaar, Dallas R. English, Sara Margolin, Anna Marie Mulligan, Alison M. Dunning, Q. Wang, C.A. Haiman, Wolfgang Janni, Paolo Radice, Nick Orr, Peter Hillemanns, Jose Esteban Castelao, B Rack, Audrey Y. Jung, Mitul Shah, Diana Eccles, Manjeet K. Bolla, Stig E. Bojesen, Henrik Flyger, Usha Menon, Kenneth Offit, A.F. Olshan, Dale P. Sandler, M.W. Beckmann, Wei Zheng, R. Kaaks, Daniele Campa, Esther M. John, Emmanouil S. Saloustros, Graham G. Giles, Michael Untch, Olivia Fletcher, Rita Katharina Schmutzler, Michael J. Lush, William G. Newman, I.L. Andrulis, Xiang Shu, Sabine Behrens, Annelie Augustinsson, Marjanka K. Schmidt, D. Gareth Evans, Heli A. Nevanlinna, SS Buys, Reiner Hoppe, Thomas Brüning, Peter Kraft, Brigid Mary Lynch, Cari Meinhold Kitahara, Melissa C. Southey, William Tapper, Per N Hall, Julian Peto, anon Investigators, Mikael Eriksson, Diether Lambrechts, Rulla M. Tamimi, Lukas Schwentner, NBCS Collaborators, Mark S. Goldberg, Jenny Chang‐Claude, Kamila Czene, Melissa H. Cessna, Renske Keeman
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Rattachement africain : us.
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Le résumé fourni par la source
Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics. Methods We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n snps =5) or sedentary time (n snps =6), or accelerometer-measured (n snps =1) or self-reported (n snps =5) vigorous physical activity. Results Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;∼8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (∼7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger). Conclusion Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.
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Les sujets associés
Nutrition, Genetics, and DiseaseNutritional Studies and DietObesity, Physical Activity, Diet