One out of two idiopathic infertile men has pathologic sperm DNA fragmentation values: Potential implications for clinical practice
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Le résumé fourni par la source
OBJECTIVES: To investigate the distribution of sperm DNA fragmentation (SDF) values and their association with clinical and seminal parameters in idiopathic infertile men. DESIGN, PATIENTS, MEASUREMENTS: Data from 3224 primary infertile men (belonging to couples having failed to conceive a pregnancy within 12 months) who underwent a thorough diagnostic work-up were analysed. A SDF value ≥ 30% (according to Sperm Chromatin Structure Assay) was considered pathologic. We excluded: (1) men with genetic abnormalities; (2) men with history of cryptorchidism; (3) men with biochemical hypogonadism; (4) men with clinical varicocele; and (5) men with other possible known aetiological factors. Descriptive statistics and logistic regression analyses were used to describe the whole cohort. RESULTS: Of all, 792 (23%) men with at least one abnormal WHO semen parameter but without any identified aetiologic factor for infertility, were considered as idiopathic infertile men. Of 792, 418 (52.7%) men had SDF ≥30%. Men with pathologic SDF were older (p = .02), had higher Follicle-stimulating hormone (FSH) (p = .04) but lower total testosterone (p = .03) values than those with SDF <30%. The homoeostatic model assessment index for insulin resistance (HOMA-IR) was higher in men with SDF ≥30% (p = .01). Idiopathic infertile men with SDF ≥30% presented with lower sperm concentration (p < .001) and lower progressive sperm motility (p < .01) than those with SDF < 30%. Logistic regression analysis revealed that older age (OR: 1.1, p = .02) and higher HOMA-IR score (OR: 1.8, p = .03) were associated with SDF ≥ 30%, after accounting for FSH and sperm concentration values. CONCLUSIONS: Approximately half of infertile men categorized as idiopathic had pathologic SDF values. Idiopathic infertile men with pathologic SDF showed worse clinical, hormonal and semen parameters than those with normal SDF values. These results suggest that including SDF testing could be clinically relevant over the real-life management work-up of infertile men.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- One out of two idiopathic infertile men has pathologic sperm DNA fragmentation values: Potential implications for clinical practice
- Date Crossref
- 21/06/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico pays non établi dans la noticeÉtablissement de santé
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Vita-Salute San Raffaele University pays non établi dans la noticeUniversité ou école supérieure
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IRCCS Ospedale San Raffaele pays non établi dans la noticeÉtablissement de santé
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University of Naples Federico II pays non établi dans la noticeUniversité ou école supérieure
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Ospedale di Circolo e Fondazione Macchi pays non établi dans la noticeÉtablissement de santé
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Department of Urology Fondazione IRCCS Ca' Granda–Ospedale Maggiore Policlinico Milan Italy pays non établi dans la noticeÉtablissement de santé
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Division of Experimental Oncology/Unit of Urology pays non établi dans la noticeInstitution
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University Vita‐Salute San Raffaele Milan Italy pays non établi dans la noticeUniversité ou école supérieure
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Urology Unit University of Naples ‘Federico II’ Naples Italy Department of Neurosciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Urology and Andrology Ospedale di Circolo and Macchi Foundation Varese Italy pays non établi dans la noticeOrganisation à but non lucratif
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Vita-Salute San Raffaele University et IRCCS Ospedale San Raffaele, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.