Effectiveness of fentanyl buccal soluble film in cancer patients with inadequate breakthrough pain control
Rattachement africain : tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Clinical evidence for the rapidity and effectiveness of fentanyl buccal soluble film (FBSF) in reducing pain intensity of breakthrough cancer pain (BTcP) remains inadequate. This study aimed to evaluate the efficacy of FBSF proportional to the around-the-clock (ATC) opioid regimens in rapidly relieving the intensity of BTcP episodes by determining the percentage of patients requiring further dose titration. METHODS: The study procedure included a dose-finding period followed by a 14-day observation period. Pain intensity was recorded with a Numeric Rating Scale (NRS) at onset and 5, 10, 15, and 30 min after FBSF self-administration. Meaningful pain relief was defined as the final NRS score ≤ 3. Satisfaction survey was conducted for each patient after treatment using the Global Satisfaction Scale. RESULTS: A total of 63 BTcP episodes occurred in 30 cancer patients. Only one patient required rescue medication at first BTcP episode and then achieved meaningful pain relief after titrating FBSF by 200 µg. Most BTcP episodes relieved within 10 min. Of 63 BTcP episodes, 30 (47.6%), 46 (73.0%), and 53 (84.1%) relieved within 5, 10, and 15 min after FBSF administration. Only grade 1/2 adverse events were reported, including somnolence, malaise, and dizziness. Of the 63 BTcP episodes, 82.6% were rated as excellent/good satisfaction with FBSF. CONCLUSION: FBSF can be administrated "on demand" by cancer patients at the onset of BTcP, providing rapid analgesia by achieving meaningful pain relief within 10 min. TRIAL REGISTRATION: This study was retrospectively registered 24 December, 2021 at Clinicaltrial.gov (NCT05209906): https://clinicaltrials.gov/study/NCT05209906 .
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Effectiveness of fentanyl buccal soluble film in cancer patients with inadequate breakthrough pain control
- Date Crossref
- 14/06/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Mackay Memorial Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Mackay Medical University pays non établi dans la noticeUniversité ou école supérieure
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Mackay Junior College of Medicine Department of Death Care Service pays non établi dans la noticeUniversité ou école supérieure
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MacKay Medical College Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Laboratory of Good Clinical Research Center pays non établi dans la noticeStructure de recherche
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Department of Otolaryngology-Head Neck Surgery pays non établi dans la noticeOrganisation à but non lucratif
Department of Internal Medicine — Mackay Memorial Hospital, Mackay Medical University et Department of Death Care Service — Mackay Junior College of Medicine, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.