Clinical drivers of hospitalisation in patients with mitochondrial diseases
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Le résumé fourni par la source
Background Mitochondrial diseases in adults are generally chronic conditions with a wide spectrum of severity contributing to disease burden and healthcare resource utilisation. Data on healthcare resource utilisation in mitochondrial diseases are limited. Objectives We performed a retrospective longitudinal study to investigate the clinical drivers of hospitalisation in adult patients with mitochondrial diseases to better understand healthcare resource utilisation. Methods We recruited participants from our specialised Mitochondrial Disease Clinic in Sydney, Australia between September 2018 and December 2021. We performed a retrospective chart review for the period 2013–2022 considering emergency department (ED) and/or hospital admission notes, as well as discharge summaries. We used multiple linear regression models to examine the association between the type of presenting symptom(s) and duration of hospital stay and frequency of admissions, while adjusting for relevant covariates. Results Of the 99 patients considered, the duration of hospitalisation ranged from 0 to 116 days per participant and the number of admissions ranged from 0 to 21 per participant. Participants with one or more mitochondrial disease-associated admissions constituted 52% of the study cohort. 13% of the participants presented to the ED without requiring an admission and 35% never attended the ED or required a hospital admission during this period. Neurological (p<0.0001), gastroenterological (p=0.01) and symptoms categorised as ‘other’ (p<0.0001) were the main presentations driving the total number of days admitted to hospital. A statistically significant association was evident for the number of admissions and all types of presenting symptoms (p<0.0001). Conclusion There are variable reasons for hospitalisation in adults with mitochondrial diseases, with neurological and gastroenterological presentations being associated with prolonged and complex hospitalisation. A better understanding of clinical drivers such as these allows for better informed and well-coordinated management aimed at optimising healthcare resource utilisation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical drivers of hospitalisation in patients with mitochondrial diseases
- Date Crossref
- 01/06/2024
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nepean Hospital Neurology pays non établi dans la noticeÉtablissement de santé
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The University of Sydney pays non établi dans la noticeUniversité ou école supérieure
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Macquarie University Centre for Economic Impacts of Genomic Medicine (GenIMPACT) pays non établi dans la noticeUniversité ou école supérieure
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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Neuroscience Research Australia pays non établi dans la noticeStructure de recherche
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Kolling Institute of Medical Research Neurogenetics pays non établi dans la noticeStructure de recherche
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Faculty of Medicine and Health pays non établi dans la noticeUniversité ou école supérieure
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Kinghorn Chair pays non établi dans la noticeInstitution
Neurology — Nepean Hospital, The University of Sydney et Centre for Economic Impacts of Genomic Medicine (GenIMPACT) — Macquarie University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.