Molecular epidemiology of infectious bronchitis virus in eastern and southern China during 2021–2023
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Le résumé fourni par la source
As a highly infectious and contagious pathogen in chickens, infectious bronchitis virus (IBV) is currently grouped into nine genotypes (GI to GIX). However, the classification of serotypes of IBV is still not clear. In this study, 270 field strains of IBV were isolated from dead or diseased chicken flocks in eastern and southern China during January 2021 to April 2023. These isolated IBV strains could be classified into 2 genotypes, GI (including 5 lineages GI-1, GI-13, GI-19, GI-22, and GI-28) and GVI based on the complete S1 sequence. Further analysis showed that the GI-19, GI-13, GI-22, GI-28, and GVI were the dominant genotypes with the proportions of 61.48, 8.89, 8.89, 7.78, and 8.89% respectively, and the homology of S1 protein of these isolates ranged from 86.85 to 100% in GI-19, 92.22 to 100% in GI-13, 83.1 to 100% in GI-22, 94.81 to 100% in GI-28 and 90.0 to 99.8% in GVI, respectively. Moreover, cross-neutralization test with sera revealed that these isolates in GI-19 lineage could be classified into at least 3 serotypes according to the antigenic relationship. In addition, structure assay using PyMOL indicated that one mutation such as S120 in receptor binding site (RBD) of GI-19 might alter the antigenicity and conformation of S protein of IBV. Overall, our data demonstrate that not only multiple genotypes, but also multiple serotypes in a single genotype or lineage have been co-circulated in eastern and southern China, providing novel insights into the molecular evolution of the antigenicity of IBV and highlighting the significance of the selection of the dominant isolate for vaccine development in IBV endemic region.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Molecular epidemiology of infectious bronchitis virus in eastern and southern China during 2021–2023
- Date Crossref
- 01/08/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Jiangsu Agri-animal Husbandry Vocational College pays non établi dans la noticeUniversité ou école supérieure
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Yangzhou University Joint International Research Laboratory of Agriculture and Agri-Product Safety pays non établi dans la noticeUniversité ou école supérieure
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China National Pharmaceutical Group Corporation (China) pays non établi dans la noticeEntreprise
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College of Veterinary Medicine Key Laboratory of Jiangsu Preventive Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Biotechnology Research laboratory pays non établi dans la noticeStructure de recherche
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Ltd. Sinopharm Yangzhou VAC Biological Engineering Co. pays non établi dans la noticeEntreprise
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Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses pays non établi dans la noticeInstitution
Jiangsu Agri-animal Husbandry Vocational College, Joint International Research Laboratory of Agriculture and Agri-Product Safety — Yangzhou University et China National Pharmaceutical Group Corporation (China), avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.