Low Macular Pigment Optical Density Is Associated with Manifest Primary Open-Angle Glaucoma in Older Women
Rattachement africain : us, Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Lower density of carotenoids lutein and zeaxanthin (L/Z) in the macula (i.e., macular pigment) has been linked to greater risk for age-related eye disease. Objectives We evaluated whether macular pigment optical density (MPOD) was associated with manifest primary open-angle glaucoma (POAG) among older women in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2). Methods MPOD was measured with customized heterochromatic flicker photometry in women who attended CAREDS2 (2016–2019) and CAREDS1 (2001–2004) study visits. Manifest POAG at CAREDS2 was assessed using visual fields, disc photos, optical coherence tomography, and medical records. Age-adjusted linear and logistic regression models were used to investigate the cross-sectional association between POAG and MPOD at CAREDS2, and MPOD measured 15 years earlier at CAREDS1. Results Among 426 CAREDS2 participants (mean age: 80 y; range: 69–98 y), 26 eyes with manifest POAG from 26 participants were identified. Glaucomatous eyes had 25% lower MPOD compared to nonglaucomatous eyes [mean (SE): 0.40 (0.05) compared with 0.53 (0.01)] optical density units (ODU), respectively ( P = 0.01). Compared with MPOD quartile 1, odds for POAG were lower for women in quartiles 2–4 ( P -trend = 0.01). After excluding eyes with age-related macular degeneration, associations were similar but not statistically significant ( P -trend = 0.16). Results were similar for MPOD measured at CAREDS1. Conclusions Our results add to growing evidence that low MPOD may be a novel glaucoma risk factor and support further studies to assess the utility of dietary interventions for glaucoma prevention.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Low Macular Pigment Optical Density Is Associated with Manifest Primary Open-Angle Glaucoma in Older Women
- Date Crossref
- 01/06/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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University of Wisconsin–Madison pays non établi dans la noticeUniversité ou école supérieure
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Medical College of Wisconsin Eye Institute pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Urbana-Champaign pays non établi dans la noticeUniversité ou école supérieure
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University of Illinois Chicago Department of Ophthalmology and Visual Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Iowa Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa Cape Town, Afrique du Sud (code pays fourni par la source)Organisation à but non lucratif
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Fred Hutch Cancer Center pays non établi dans la noticeOrganisation à but non lucratif
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University of Wisconsin-Madison Department of Ophthalmology and Visual Sciences pays non établi dans la noticeUniversité ou école supérieure
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Fred Hutchinson Cancer Research Center Department of Cancer Prevention pays non établi dans la noticeStructure de recherche
University of Wisconsin–Madison, Eye Institute — Medical College of Wisconsin et University of Illinois Urbana-Champaign, avec 6 autres affiliations. Pays d’affiliation : Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.