Oral Candida albicans strain diversity and maintenance in HIV positive women in South Africa
Rattachement africain : Nigéria, Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: This study investigated C. albicans strain diversity and maintenance in the oral cavity of HIV positive women over a 6 month period. STUDY DESIGN: C. albicans strains were isolated from 17 HIV positive women at Charlotte Maxeke Academic Hospital, Johannesburg at 3 intervals over a 6 month period. Strains were genotyped using ABC and Multilocus Sequence Typing (MLST) techniques. In the MLST technique, for each strain, a Diploid Sequence Type (DST) number was obtained. Using cluster analysis, an Unweighted Pair Group Method with Arithmetic Mean (UPGMA) dendrogram and a matrix of strain similarities were generated. Strains were also compared to the previous South African isolates documented in the MLST database. RESULTS: Ninety four percent of women carried the same ABC genotype for 6 months. MLST technique, showed that ten women (58.8%) carried the same DST at 2 visits, while seven (41.2%) carried different DST at all visits. Further analysis showed that 64.7% of women were recolonised with different strains and 35.3% carried the same strains of C. albicans with heterozygosity. A total of 40 diploid sequence types were identified of which 27 DSTs were unique to this study group that were added to the MLST database. Most of the strains were closely related to previously isolated strains from South Africa. CONCLUSION: Recolonization of the oral cavity with different strains and microevolution of the original strains of C. albicans can occur, which can be a potential problem for HIV patients, in whom highly virulent and drug resistant strains can emerge.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Oral Candida albicans strain diversity and maintenance in HIV positive women in South Africa
- Date Crossref
- 01/08/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Obafemi Awolowo University Nigéria (code pays fourni par la source)Université ou école supérieure
-
University of the Witwatersrand University of the Witwatersrand, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
-
School of Pathology Department of Clinical Microbiology and Infectious Diseases Ile-Ife, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
-
Faculty of Dentistry Ile-Ife, Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
-
Department of Oral Biological Sciences School of Oral Health Sciences University of The Witwatersrand, Afrique du Sud (pays nommé en fin d’affiliation)Université ou école supérieure
Obafemi Awolowo University (Nigéria), University of the Witwatersrand (University of the Witwatersrand, Afrique du Sud) et Department of Clinical Microbiology and Infectious Diseases — School of Pathology (Ile-Ife, Nigéria), avec 2 autres affiliations. Pays d’affiliation : Nigéria, Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.