Targeting Sedentary Behavior in Older Adults: Subgroup Analysis of a Randomized Clinical Trial

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Background: Sedentary behavior (spending most of the awake hours in sitting/lying posture) is associated with increased mortality in CKD but few studies have examined the feasibility of interventions targeting sedentary behavior in older adults with CKD. Methods: The Sit Less, Interact, Move More (SLIMM) Study was a 24-week RCT of an intervention to reduce sedenary duration with stepping duration in participants with CKD. Physical activity was measured using a mid-thigh accelerometer worn for 7 days before baseline and q4 weeks in standard of care (SOC) group (N=52) and baseline and q8 weeks in SLIMM group (N=54). Based on the accelerometry data, SLIMM group was provided instructions on reducing sedentary duration. In this post-hoc analyses, we used mixed effect models to compare the effects of the SLIMM intervention in participants age ≥ 70 (N =59) versus age < 70 (N=47). Results: Age ≥ 70 group compared to age < 70 group had a higher % of Whites and lower % of stage3b-5 CKD (Table 1). While sedentary duration was similar, the older group had lower stepping duration, gait speed and 6-min walk distance (Table 1). In mixed models, there were no significant differences between SLIMM and SOC groups for sedentary (1, 95% CI -39 to 42 min/d) and stepping (-4, 95% CI -18 to 11 min/d) durations and the number of steps/day (-424, 95% CI -1669 to 820) in the age < 70 group. The corresponding numbers for the age ≥ 70 group for sedentary and stepping durations and the number of steps/d were -28, (95% CI -61 to 5 min/d), 13, (95% CI 1 to 24 min/d) and 1330, (95% CI 322 to 2338 min/d), respectively. Conclusions: It is feasible to decrease sedenaray behavior In older adults with CKD. Funding: NIDDK Support, Other NIH Support - NHLBI, Veterans Affairs Support Baseline characteristics between age group

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