Cefradine Schiff Bases and their Metal Salts as Potential Anti-infective Agents

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Introduction: A series of schiff bases(3-8) were synthesized by the reaction of cefradine with six different aldehydes/ketones. Methods: These Schiff bases (3-8) were treated with different bases/salts (NaOH, KOH, Ca(OH)2, Ba(OH)2, Ag(NO)3) to get their metal salts. The structures of the products were as-certained by spectroscopic data. The synthesized compounds were tested for biological activities against Staphylococcus aureus (gram-positive bacterium) and Escherichia coli (gram-negative bacterium). Results: In general, low activities in most of the synthesized compounds were observed. Conclusion: A general reduction in the activities of most of the synthesized compounds in com-parison to cefradine can be linked to the unavailability of the free amino group of cefradine by its involvement in the synthesis of imine derivatives.

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