Abstract P108: Stroke Incidence and High Sensitivity C-reactive Protein Among African Americans: The Jackson Heart Study
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Le résumé fourni par la source
In the United States, strokes are a leading cause of death and disabilities, especially for older adults; however, effective biological markers to predict stroke remain elusive. The objective of this study was to investigate the association between inflammation, as measured by high-sensitivity c-reactive protein (hs-CRP) and stroke incidence among African Americans (AA) enrolled in a community-based longitudinal observational study, the Jackson Heart Study.Baseline hs-CRP levels were categorized in quintiles: Quintile 1 (0.0084 mg/L); Quintile 2 (0.0085 - 0.0189 mg/L); Quintile 3 (0.0190 - 0.036 mg/L); Quintile 4 (0.037 - 0.0675 mg/L); Quintile 5 (≥ 0.0676 mg/L). Stroke risk factors/covariates were compared across hs-CRP tertiles. Continuous variables were compared using a one-way ANOVA, and a Chi-Square test was used for categorical variables. To determine whether baseline hs-CRP levels were associated with stroke incidence, Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CI).Results from the unadjusted model of the Cox regression indicates hs-CRP levels in quintile 2 (HR 1.48; 95% CI 0.96-2.29), quintile 3 (HR 1.44; 95% CI 0.93-2.24), and quintile 4 (HR 1.09; 95% CI 0.68-1.74) were not associated with stroke incidence when compared to quintile 1 (reference). Participants with the highest hs-CRP levels, quintile 5, were at an increased risk for stroke (HR 1.78; 95% CI 1.17-2.72) compared to the reference quintile. In a fully adjusted model including risk factors and mediators for stroke/hs-CRP (demographics, anthropometrics, health condition covariates, health behavioral risk factors, and cardiovascular disease history), the increased stroke risk incidence remained present for quintile 5 (HR 1.87; 95% CI 1.17-2.98) compared to reference quintile 1.Overall, these results corroborate previous studies’ findings in Black Americans that hs-CRP is associated with stroke incidence only at most severe levels. Although several studies have demonstrated higher hs-CRP in AAs, there have been a lesser association of hs-CRP and cardiovascular disease; hence, these findings provide new insights that hs-CRP l may not be a reliable predictor for stroke incidence among AAs.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract P108: Stroke Incidence and High Sensitivity C-reactive Protein Among African Americans: The Jackson Heart Study
- Date Crossref
- 19/03/2024
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Institute for Advanced Journalism Studies pays non établi dans la noticeOrganisation à but non lucratif
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The University of Texas Southwestern Medical Center pays non établi dans la noticeÉtablissement de santé
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University of California pays non établi dans la noticeUniversité ou école supérieure
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Univ of Texas Southwestern pays non établi dans la noticeUniversité ou école supérieure
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Institute for Advanced Journalism Studies, The University of Texas Southwestern Medical Center et University of California, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.