Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer
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Le résumé fourni par la source
Essential trace elements are micronutrients whose deficiency has been associated with altered fertility and/or adverse pregnancy outcomes, while surplus may be toxic. The concentrations of eight essential trace elements were measured using inductively coupled mass spectrometry (ICP-MS) and assessed with respect to clinical in vitro fertilization (IVF) outcomes in a population of 51 women undergoing IVF with intracytoplasmic sperm injection (ICSI), pre-implantation genetic screening for aneuploidy (PGT-A), and single frozen euploid embryo transfer (SET/FET). Specifically, copper (Cu), zinc (Zn), molybdenum, selenium, lithium, iron, chromium, and manganese were quantified in follicular fluid and whole blood collected the day of vaginal oocyte retrieval (VOR) and in urine collected the day of VOR and embryo transfer. We found that the whole blood Cu/Zn ratio was significantly associated with superior responses to ovarian stimulation. Conversely, the whole blood zinc and selenium concentrations were significantly associated with poor ovarian response outcomes. Higher levels of whole blood zinc and selenium, urinary selenium, lithium, and iron had significant negative associations with embryologic outcomes following IVF. Regarding clinical IVF outcomes, higher urinary molybdenum concentrations the day of VOR were associated with significantly lower odds of implantation and live birth, while higher urinary Cu/Mo ratios on the day of VOR were associated with significantly higher odds of implantation, clinical pregnancy, and live birth. Our results suggest that essential trace element levels may directly influence the IVF outcomes of Spanish patients, with selenium and molybdenum exerting negative effects and copper-related ratios exerting positive effects. Additional studies are warranted to confirm these relationships in other human populations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer
- Date Crossref
- 15/05/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Instituto de Investigación Sanitaria La Fe pays non établi dans la noticeOrganisation à but non lucratif
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Valencian Infertility Institute pays non établi dans la noticeStructure de recherche
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IVIRMA Global pays non établi dans la noticeÉtablissement de santé
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Centro de Investigaciones Energéticas pays non établi dans la noticeStructure de recherche
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Universitat de València pays non établi dans la noticeUniversité ou école supérieure
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IVI Foundation IVI-RMA Global Research Alliance pays non établi dans la noticeOrganisation à but non lucratif
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IVI-RMA Global Research Alliance pays non établi dans la noticeInstitution
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Unit of Mass Spectrometry and Geochemical Applications pays non établi dans la noticeInstitution
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Faculty of Medicine of Valencia Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
Instituto de Investigación Sanitaria La Fe, Valencian Infertility Institute et IVIRMA Global, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.