Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance
Rattachement africain : cn, hk, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Obstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and cognitive impairments. However, the causal association of OSA with brain morphology and cognitive performance has not been determined. METHODS: We conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between OSA and a range of neurocognitive characteristics, including brain cortical structure, brain subcortical structure, brain structural change across the lifespan, and cognitive performance. Summary-level GWAS data for OSA from the FinnGen consortium was used to identify genetically predicted OSA. Data regarding neurocognitive characteristics were obtained from published meta-analysis studies. Linkage disequilibrium score regression analysis was employed to reveal genetic correlations between OSA and related traits. RESULTS: Our MR study provided evidence that OSA was found to significantly increase the volume of the hippocampus (IVW β (95% CI) = 158.997 (76.768 to 241.227), P = 1.51e-04), with no heterogeneity and pleiotropy detected. Nominally causal effects of OSA on brain structures, such as the thickness of the temporal pole with or without global weighted, amygdala structure change, and cerebellum white matter change covering lifespan, were observed. Bidirectional causal links were also detected between brain cortical structure, brain subcortical, cognitive performance, and OSA risk. LDSC regression analysis showed no significant correlation between OSA and hippocampus volume. CONCLUSIONS: Overall, we observed a positive association between genetically predicted OSA and hippocampus volume. These findings may provide new insights into the bidirectional links between OSA and neurocognitive features, including brain morphology and cognitive performance.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Elucidating the association of obstructive sleep apnea with brain structure and cognitive performance
- Date Crossref
- 06/05/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shanghai Jiao Tong University pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Ninth People's Hospital pays non établi dans la noticeÉtablissement de santé
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Nanjing General Hospital of Nanjing Military Command pays non établi dans la noticeÉtablissement de santé
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Nanjing University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Chinese University of Hong Kong pays non établi dans la noticeUniversité ou école supérieure
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Stanford Medicine pays non établi dans la noticeÉtablissement de santé
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Stanford University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Stomatological Hospital pays non établi dans la noticeÉtablissement de santé
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College of Stomatology Department of Oral and Cranio-Maxillofacial Surgery pays non établi dans la noticeUniversité ou école supérieure
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JC School of Public Health and Primary Care pays non établi dans la noticeUniversité ou école supérieure
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital et Nanjing General Hospital of Nanjing Military Command, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.