Metabolic Syndrome in people treated with Antipsychotics (RISKMet): A multimethod study protocol investigating genetic, behavioural, and environmental risk factors
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Le résumé fourni par la source
INTRODUCTION: The RISKMet project aims to: (1) identify risk factors for metabolic syndrome (MetS) by comparing patients with and without MetS; (2) characterise patients treated with second-generation antipsychotics (SGAs) about MetS diagnosis; (3) study behavioural patterns, including physical activity (PA) and dietary habits, in patients and healthy individuals using a prospective cohort design. METHOD: The RISKMet project investigates MetS in individuals treated with SGAs, focusing on both adult and paediatric populations. The study utilizes a case-control design to examine potential risk factors for MetS, categorizing participants as MetS+ considered as "Cases" and MetS- considered as "Controls" matched by sex and age. The evaluation of factors such as MetS, lifestyle habits, and environmental influences is conducted at two time points, T0 and T3, after 3 months. Subsequently, the project aims to assess body parameters, including physical examinations, and blood, and stool sample collection, to evaluate metabolic markers and the impact of SGAs. The analysis includes pharmacological treatment data and genetic variability. Behavioural markers related to lifestyle, eating behaviour, PA, and mood are assessed at both T0 and T3 using interviews, accelerometers, and a mobile app. The study aims to improve mental and physical well-being in SGA-treated individuals, establish a biobank for MetS research, build an evidence base for physical health programs, and develop preventive strategies for SGA-related comorbidities. CONCLUSIONS: This project innovates MetS monitoring in psychiatry by using intensive digital phenotyping, identifying biochemical markers, assessing familial risks, and including genetically similar healthy controls. STUDY REGISTRATION NUMBER: ISRCTN18419418 at www.isrctn.com.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Metabolic Syndrome in people treated with Antipsychotics (RISKMet): A multimethod study protocol investigating genetic, behavioural, and environmental risk factors
- Date Crossref
- 01/05/2024
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Centro San Giovanni di Dio Fatebenefratelli pays non établi dans la noticeÉtablissement de santé
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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University of Palermo Department of Biomedicine pays non établi dans la noticeUniversité ou école supérieure
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Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Naples Federico II pays non établi dans la noticeUniversité ou école supérieure
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IRCCS Eugenio Medea Child and Adolescent Psychiatry Unit pays non établi dans la noticeStructure de recherche
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University of Brescia Department of Molecular and Translational Medicine pays non établi dans la noticeUniversité ou école supérieure
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Pegaso University pays non établi dans la noticeUniversité ou école supérieure
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Unit of Epidemiological and Evaluation Psychiatry pays non établi dans la noticeInstitution
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AOU Policlinico "Federico II" pays non établi dans la noticeÉtablissement de santé
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University "Federico II" Department of Clinical Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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University of Naples "Federico II" Education for Health and Sustainable Development pays non établi dans la noticeUniversité ou école supérieure
Centro San Giovanni di Dio Fatebenefratelli, Istituti di Ricovero e Cura a Carattere Scientifico et Department of Biomedicine — University of Palermo, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.