Chest X-Ray–Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study
Rattachement africain : es, us, Afrique du Sud, Mozambique. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnostic tests, underscores the need for improved tools to enhance diagnosis and care in resource-limited settings. OBJECTIVE: This study aims to present a telemedicine web platform, BITScreen PTB (Biomedical Image Technologies Screen for Pediatric Tuberculosis), aimed at improving the evaluation of pulmonary TB in children based on digital chest x-ray (CXR) imaging and clinical information in resource-limited settings. METHODS: The platform was evaluated by 3 independent expert readers through a retrospective assessment of a data set with 218 imaging examinations of children under 3 years of age, selected from a previous study performed in Mozambique. The key aspects assessed were the usability through a standardized questionnaire, the time needed to complete the assessment through the platform, the performance of the readers to identify TB cases based on the CXR, the association between the TB features identified in the CXRs and the initial diagnostic classification, and the interreader agreement of the global assessment and the radiological findings. RESULTS: The platform's usability and user satisfaction were evaluated using a questionnaire, which received an average rating of 4.4 (SD 0.59) out of 5. The average examination completion time ranged from 35 to 110 seconds. In addition, the study on CXR showed low sensitivity (16.3%-28.2%) but high specificity (91.1%-98.2%) in the assessment of the consensus case definition of pediatric TB using the platform. The CXR finding having a stronger association with the initial diagnostic classification was air space opacification (χ21>20.38, P<.001). The study found varying levels of interreader agreement, with moderate/substantial agreement for air space opacification (κ=0.54-0.67) and pleural effusion (κ=0.43-0.72). CONCLUSIONS: Our findings support the promising role of telemedicine platforms such as BITScreen PTB in enhancing pediatric TB diagnosis access, particularly in resource-limited settings. Additionally, these platforms could facilitate the multireader and systematic assessment of CXR in pediatric TB clinical studies.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Chest X-Ray–Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study
- Date Crossref
- 01/07/2024
- Éditeur
- JMIR Publications Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Biomedical Research Networking Center in Bioengineering pays non établi dans la noticeInstitution
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Universidad Politécnica de Madrid pays non établi dans la noticeUniversité ou école supérieure
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George Washington University Hospital pays non établi dans la noticeÉtablissement de santé
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Hospital General de Catalunya pays non établi dans la noticeÉtablissement de santé
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Desmond Tutu HIV Foundation Afrique du Sud (code pays fourni par la source)Organisation à but non lucratif
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Stellenbosch University Stellenbosch University, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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Instituto de Salud Carlos III Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) pays non établi dans la noticeOrganisme public
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Hospital General Universitario Gregorio Marañón pays non établi dans la noticeÉtablissement de santé
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Centro de Investigación Biomédica en Red pays non établi dans la noticeStructure de recherche
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Centro de Investigación Biomédica en Red Enfermedades Infecciosas pays non établi dans la noticeStructure de recherche
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Instituto de Investigación Sanitaria Gregorio Marañón pays non établi dans la noticeStructure de recherche
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HM Hospitales Radiología Pediátrica pays non établi dans la noticeÉtablissement de santé
Biomedical Research Networking Center in Bioengineering, Universidad Politécnica de Madrid et George Washington University Hospital, avec 9 autres affiliations. Pays d’affiliation : Afrique du Sud, Mozambique.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.