Mechanisms producing Tinnitus. An experimental model

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Purpose Tinnitus can also be induced by medications, such as salicylate. Purpose of the study was is to determine whether different concentrations of salicylate can cause tinnitus of different intensity. Methods For the purposes of this study 60 male Wistar rats were used. The animals were divided into 5 groups (12 rats in each group). The animals that did not receive any substance were allocated to the control group (Group A). The second group (Group B) of rats received salicylate (Sigma Aldrich) intraperitoneally for 7 days (300mg/Kg/day). The 3rd group (Group C) received salicylate intraperitoneally for 7 days, but at twice the concentration of the animals in the second group (600mg/kg/d). The 4th group (Group D) simultaneously received salicylate (300mg/Kg/day) and pure Memantine (Sigma Aldrich, 10 mg/kg/d) intraperitoneally for 7 days. The 5th group (Group E) did not receive any substance but was exposed for 168 consecutive hours (7 days) to sound to induce tinnitus. Results Differences in DPOAE-amplitudes, and therefore in cochlear activity, were observed between the first four experimental groups. The DPOAEs of animals treated either with salicylate as monotherapy or salicylate combined with memantine were indistinguishable from the noise floor, did not differ significantly compared to the animals of the control group or those expose to constant noise. The cochlear structures of Group E remained anatomically and functionally unaffected from the exposure to constant noise. Conclusions The administration of memantine does not contribute significantly to the reduction of tinnitus. When tinnitus is the result of continuous exposure to intense sound, the appearance of tinnitus is not caused by loss of auditory perception, at least in the first stages. Publication History Article published online: 19 April 2024 © 2024. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany

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