Phylodynamic and Evolution of the Hemagglutinin (HA) and Neuraminidase (NA) Genes of Influenza A(H1N1) pdm09 Viruses Circulating in the 2009 and 2023 Seasons in Italy
Rattachement africain : it, br. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The influenza A(H1N1) pdm09 virus, which emerged in 2009, has been circulating seasonally since then. In this study, we conducted a comprehensive genome-based investigation to gain a detailed understanding of the genetic and evolutionary characteristics of the hemagglutinin (HA) and neuraminidase (NA) surface proteins of A/H1N1pdm09 strains circulating in Italy over a fourteen-year period from 2009 to 2023 in relation to global strains. Phylogenetic analysis revealed rapid transmission and diversification of viral variants during the early pandemic that clustered in clade 6B.1. In contrast, limited genetic diversity was observed during the 2023 season, probably due to the genetic drift, which provides the virus with a constant adaptability to the host; furthermore, all isolates were split into two main groups representing two clades, i.e., 6B.1A.5a.2a and its descendant 6B.1A.5a.2a.1. The HA gene showed a faster rate of evolution compared to the NA gene. Using FUBAR, we identified positively selected sites 41 and 177 for HA and 248, 286, and 455 for NA in 2009, as well as sites 22, 123, and 513 for HA and 339 for NA in 2023, all of which may be important sites related to the host immune response. Changes in glycosylation acquisition/loss at prominent sites, i.e., 177 in HA and 248 in NA, should be considered as a predictive tool for early warning signs of emerging pandemics, and for vaccine and drug development.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Phylodynamic and Evolution of the Hemagglutinin (HA) and Neuraminidase (NA) Genes of Influenza A(H1N1) pdm09 Viruses Circulating in the 2009 and 2023 Seasons in Italy
- Date Crossref
- 17/04/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Sassari Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Istituto Superiore di Sanità pays non établi dans la noticeOrganisme public
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University Niccolò Cusano pays non établi dans la noticeUniversité ou école supérieure
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Università Campus Bio-Medico pays non établi dans la noticeUniversité ou école supérieure
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Fundação Oswaldo Cruz pays non établi dans la noticeStructure de recherche
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National HIV/AIDS Research Center (CNAIDS) pays non établi dans la noticeStructure de recherche
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Laboratorio di Biologia Molecolare—Fondazione Università Niccolò Cusano pays non établi dans la noticeInstitution
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Climate Amplified Diseases and Epidemics (CLIMADE) pays non établi dans la noticeInstitution
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Department of Sciences and Technologies for Sustainable Development and One Health pays non établi dans la noticeInstitution
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Instituto René Rachou pays non établi dans la noticeStructure de recherche
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University Campus Bio-Medico of Rome Unit of Medical Statistics and Molecular Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Department of Biomedical Sciences — University of Sassari, Istituto Superiore di Sanità et University Niccolò Cusano, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.