COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies

Le résumé fourni par la source

Aim: Kidney transplant recipients (KTRs), due to their immunosuppressed status, are potentially more susceptible to both the severe effects of COVID-19 and complications in their transplanted organ.The aim of this study is to investigate whether COVID-19 infection increases the risk of rejection in kidney transplant recipients (KTRs).Methods: This study involved a detailed literature review, conducted using PubMed, with the search being completed by September 7th, 2023.The search strategy incorporated a combination of relevant keywords: 'COVID' , 'Renal' , 'Kidney' , 'Transplant' , and 'Rejection' .The results from controlled and uncontrolled studies were separately collated and analyzed.Results: A total of 11 studies were identified, encompassing 1,179 patients.Among these, two controlled studies reported the incidence of rejection in KTRs infected with COVID-19.Pooling data from these studies revealed no significant statistical correlation between COVID-19 infection and biopsy-proven rejection (p = 0.26).In addition, nine non-controlled studies were found, with rejection incidences ranging from 0% to 66.7%.The majority of these studies (eight out of nine) had small sample sizes, ranging from 3 to 75 KTRs, while the largest included 372 KTRs.The combined rejection rate across these studies was calculated to be 11.8%.Conclusion: In conclusion, the limited number of published controlled studies revealed no statistically significant association between COVID-19 infection and biopsy-proven rejection among KTRs.However, the broader analysis of non-controlled studies showed a variable rejection incidence with a pooled rejection rate of 11.8%.There is insufficient high-quality data to explore the association of COVID-19 infection and rejection.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.