Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development
Rattachement africain : hu, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
In this present study, the material science background of crosslinked gelatin (GEL) was investigated. The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, and their ability to withstand heat sterilization was evaluated. The impact of different crosslinkers on matrix properties was analyzed. It was found that matrices crosslinked with butanediol diglycidyl ether (BDDE) and poly(ethylene glycol) diglycidyl ether (PEGDE) were resistant to enzymatic degradation and heat sterilization. Additionally, at 1 v/v % crosslinker concentration, the crosslinked weight was lower than the starting weight, suggesting simultaneous degradation and crosslinking. The crosslinked weight and swelling ratio were optimal in the case of the matrices that were crosslinked with 3% and 5% v/v BDDE and PEGDE. FTIR analysis confirmed crosslinking, and the reduction of free primary amino groups indicated effective crosslinking even at a 1% v/v crosslinker concentration. Moreover, stress–strain and compression characteristics of the 5% v/v BDDE crosslinked matrix were comparable to native gelatin. Based on material science measurements, the crosslinked matrices may be promising candidates for scaffold development, including properties such as resistance to enzymatic degradation and heat sterilization.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development
- Date Crossref
- 14/04/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Semmelweis University Institute of Translational Medicine pays non établi dans la noticeUniversité ou école supérieure
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Budapest University of Technology and Economics pays non établi dans la noticeUniversité ou école supérieure
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Institute of Materials and Environmental Chemistry pays non établi dans la noticeStructure de recherche
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HUN-REN Research Centre for Natural Sciences pays non établi dans la noticeStructure de recherche
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University of Sassari Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Győr Department of Materials Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Chemical Technology and Biotechnology Laboratory of Plastics and Rubber Technology pays non établi dans la noticeUniversité ou école supérieure
Institute of Translational Medicine — Semmelweis University, Budapest University of Technology and Economics et Institute of Materials and Environmental Chemistry, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.