Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review
Rattachement africain : ir, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: We conducted this systematic review to compile the evidence for the role of neutrophil to lymphocyte ratio (NLR) in odontogenic infection (OI) and to determine whether NLR is elevated in patients with OI. This was done to aid physicians in better understanding this condition for clinical management. METHODS: The search was conducted on PubMed, Scopus, and Web of Science libraries on March 30, 2023. Two reviewers independently screened the studies using Endnote software. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies. RESULTS: A total of nine studies were included in the review. Among patients with OI, positive and statistically significant correlations of NLR were seen with more severe disease, a prolonged hospital stay, postoperative requirement of antibiotics, and total antibiotic dose needed. In the receiver operating characteristics (ROC) analysis, the optimum cut-off level of NLR was 5.19 (specificity: 81, sensitivity: 51). In addition, NLR was correlated with preoperative fever (p = 0.001). Among patients with Ludwig's Angina, NLR could predict disease severity and length of stay in the hospital (p = 0.032 and p = 0.033, respectively). In addition, the relationship between the NLR and mortality was statistically significant (p = 0.026, specificity of 55.5%, and sensitivity of 70.8%). Among patients with severe oral and maxillofacial space infection, a positive correlation was found between IL-6 and CRP with NLR (rs = 0.773, P = 0.005 and rs = 0.556, P = 0.020, respectively). Also, a higher NLR was considered an essential predictor of organ involvement (P = 0.027) and the number of complications (P = 0.001). However, among diabetes mellitus (DM) patients afflicted with submandibular abscesses, NLR had no association with therapeutic response. CONCLUSIONS: Many people around the world suffer from OI, and a cheap and fast biomarker is needed for it. Interestingly, inflammation plays a role in this infection, and elevated NLR levels can be a good biomarker of inflammation and, as a result, for OI progression.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review
- Date Crossref
- 28/03/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tabriz University of Medical Sciences Dental school pays non établi dans la noticeUniversité ou école supérieure
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Islamic Azad University Dental Branch of Tehran pays non établi dans la noticeUniversité ou école supérieure
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Islamic Azad University Medical Branch of Tehran pays non établi dans la noticeUniversité ou école supérieure
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Shiraz University of Medical Sciences Trauma Research Center pays non établi dans la noticeUniversité ou école supérieure
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Tehran University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Florida Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Dentistry Dental Research Center pays non établi dans la noticeUniversité ou école supérieure
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Islamic Azad University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Student Research Committee pays non établi dans la noticeUniversité ou école supérieure
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Tehran University of medical and health sciences Medical School pays non établi dans la noticeUniversité ou école supérieure
Dental school — Tabriz University of Medical Sciences, Islamic Azad University Dental Branch of Tehran et Islamic Azad University Medical Branch of Tehran, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.