Nipple-Sparing Mastectomy and Adequate Margins for Patients With Ductal Carcinoma In Situ
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Le résumé fourni par la source
BackgroundFor patients with ductal carcinoma in situ (DCIS) undergoing breast conservation surgery (BCS), guidelines advise a margin width of at least 2 mm, with studies demonstrating decreased recurrence risk compared to narrower margins. However, limited data exist establishing if this margin is appropriate in mastectomies, and specifically for nipple-sparing mastectomy (NSM). Consequently, we evaluated the margins of DCIS patients undergoing NSM and resulting oncologic outcomes.MethodsA single-institution retrospective review was performed in patients with DCIS or DCIS with microinvasion (DCIS + MI) undergoing NSM from April 2010 to December 2021. Patient and tumor characteristics, margin status, treatment, and outcomes information were collected. The association between margins and local-regional (LRR) and distant recurrence (DR) were examined.Results161 patients were included, comprising 284 NSM (164 therapeutic, 120 prophylactic). 153 patients had DCIS and 8 had DCIS + MI. Most patients had hormone sensitive, 123 (76.4%), and nuclear grade 2, 72 (44.7%), disease. In total, 35 (21.7%) patients had positive or <2 mm margins. Of these, 21 (60%) involved the anterior margin. At a median follow-up of 45 months (range 0-151), 2.5% (n = 4) had a LRR and .6% (n = 1) had a DR. Of patients with a recurrence, only 2 had positive or <2 mm margins, 1 had received endocrine therapy, and none received adjuvant radiation.DiscussionNo specific margin status was found to correlate with recurrence for patients with DCIS or DCIS + MI undergoing NSM, with an altogether low recurrence risk. Overall, this suggests that recommended DCIS margins in BCS doesn't necessarily apply in NSM, where margins of <2 mm may be acceptable.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Nipple-Sparing Mastectomy and Adequate Margins for Patients With Ductal Carcinoma In Situ
- Date Crossref
- 11/04/2024
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of North Carolina at Chapel Hill pays non établi dans la noticeUniversité ou école supérieure
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Cancer Institute (WIA) pays non établi dans la noticeÉtablissement de santé
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Novant Health Department of Surgical Oncology pays non établi dans la noticeÉtablissement de santé
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Women & Infants Hospital of Rhode Island pays non établi dans la noticeÉtablissement de santé
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University of Wisconsin–Green Bay pays non établi dans la noticeUniversité ou école supérieure
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University of North Carolina School of Medicine Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Women and Infants Hospital and Breast Surgery pays non établi dans la noticeÉtablissement de santé
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Green Bay Oncology pays non établi dans la noticeInstitution
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Division of Surgical Oncology pays non établi dans la noticeInstitution
University of North Carolina at Chapel Hill, Cancer Institute (WIA) et Department of Surgical Oncology — Novant Health, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.