Remote Monitoring and Data Collection for Decentralized Clinical Trials
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Le résumé fourni par la source
Importance: Less than 5% of patients with cancer enroll in a clinical trial, partly due to financial and logistic burdens, especially among underserved populations. The COVID-19 pandemic marked a substantial shift in the adoption of decentralized trial operations by pharmaceutical companies. Objective: To assess the current global state of adoption of decentralized trial technologies, understand factors that may be driving or preventing adoption, and highlight aspirations and direction for industry to enable more patient-centric trials. Design, Setting, and Participants: The Bloomberg New Economy International Cancer Coalition, composed of patient advocacy, industry, government regulator, and academic medical center representatives, developed a survey directed to global biopharmaceutical companies of the coalition from October 1 through December 31, 2022, with a focus on registrational clinical trials. The data for this survey study were analyzed between January 1 and 31, 2023. Exposure: Adoption of decentralized clinical trial technologies. Main Outcomes and Measures: The survey measured (1) outcomes of different remote monitoring and data collection technologies on patient centricity, (2) adoption of these technologies in oncology and all therapeutic areas, and (3) barriers and facilitators to adoption using descriptive statistics. Results: All 8 invited coalition companies completed the survey, representing 33% of the oncology market by revenues in 2021. Across nearly all technologies, adoption in oncology trials lags that of all trials. In the current state, electronic diaries and electronic clinical outcome assessments are the most used technology, with a mean (SD) of 56% (19%) and 51% (29%) adoption for all trials and oncology trials, respectively, whereas visits within local physician networks is the least adopted at a mean (SD) of 12% (18%) and 7% (9%), respectively. Looking forward, the difference between the current and aspired adoption rate in 5 years for oncology is large, with respondents expecting a 40% or greater absolute adoption increase in 8 of the 11 technologies surveyed. Furthermore, digitally enabled recruitment, local imaging capabilities, and local physician networks were identified as technologies that could be most effective for improving patient centricity in the long term. Conclusions and Relevance: These findings may help to galvanize momentum toward greater adoption of enabling technologies to support a new paradigm of trials that are more accessible, less burdensome, and more inclusive.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Remote Monitoring and Data Collection for Decentralized Clinical Trials
- Date Crossref
- 12/04/2024
- Éditeur
- American Medical Association (AMA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Memorial Sloan Kettering Cancer Center pays non établi dans la noticeÉtablissement de santé
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Cornell University pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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University of Toronto Princess Margaret Cancer Center pays non établi dans la noticeUniversité ou école supérieure
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Princess Margaret Cancer Centre pays non établi dans la noticeÉtablissement de santé
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University of Chicago Medical Center Center for Clinical Cancer Genetics and Global Health pays non établi dans la noticeÉtablissement de santé
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Cancer Genetics (United States) pays non établi dans la noticeEntreprise
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United States Food and Drug Administration pays non établi dans la noticeOrganisme public
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Susan G. Komen Breast Cancer Foundation pays non établi dans la noticeOrganisation à but non lucratif
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Amgen (United States) pays non établi dans la noticeEntreprise
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Johnson & Johnson (United States) pays non établi dans la noticeEntreprise
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Janssen (United States) pays non établi dans la noticeEntreprise
Memorial Sloan Kettering Cancer Center, Cornell University et Johns Hopkins University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.