Transdifferentiation is uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Death of mechanosensory hair cells in the inner ear is a common cause of auditory and vestibular impairment in mammals, which have a limited ability to regrow these cells after damage. In contrast, non-mammalian vertebrates including zebrafish can robustly regenerate hair cells following severe organ damage. The zebrafish inner ear provides an understudied model system for understanding hair cell regeneration in organs that are highly conserved with their mammalian counterparts. Here we quantitatively examine hair cell addition during growth and regeneration of the larval zebrafish inner ear. We used a genetically encoded ablation method to induce hair cell death and observed gradual regeneration with correct spatial patterning over two weeks following ablation. Supporting cells, which surround and are a source of new hair cells, divide in response to hair cell ablation, expanding the possible progenitor pool. In parallel, nascent hair cells arise from direct transdifferentiation of progenitor pool cells uncoupled from progenitor division. These findings reveal a previously unrecognized mechanism of hair cell regeneration with implications for how hair cells may be encouraged to regenerate in the mammalian ear.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Transdifferentiation is uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear
- Date Crossref
- 11/04/2024
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Cellular Research (United States) pays non établi dans la noticeEntreprise
-
University of Washington pays non établi dans la noticeUniversité ou école supérieure
-
Molecular and Cellular Biology Graduate Program pays non établi dans la noticeInstitution
-
Virginia Merrill Bloedel Hearing Research Center pays non établi dans la noticeStructure de recherche
-
Neuroscience Graduate Program pays non établi dans la noticeInstitution
Cellular Research (United States), University of Washington et Molecular and Cellular Biology Graduate Program, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.