A Fractional Viscoelastic Mechanical Model for Speed Optimization of Robotic Cell Microinjection
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Robotic microinjection has been widely applied in the biomedical field as an effective means of cell micromanipulation. To improve the survival rate and efficiency of injection, the puncture speed should be designed properly to minimize cell damage. However, due to the complex viscoelastic mechanical properties of cells and the physical constraints of micromanipulation systems, speed optimization has become a very challenging task. To this end, this article proposes a new fractional model to accurately describe the viscoelastic mechanical properties of cells, and develops a speed optimization method based on this model to achieve minimal cell damage. Different from the traditional integer models, the proposed model is implemented by introducing a fractional viscoelastic element “spring-pot” to replace the viscous damping in the classical standard linear solid model. By this way, the model can simultaneously characterize the power-law relaxation and creep behaviors of cells in microinjection with higher accuracy and fewer parameters. In addition, with the proposed model and a class of polynomials, the speed optimization problem is formulated and solved to minimize the cell deformation subjected to physical constraints. To verify the effectiveness of the proposed model and optimization algorithm, zebrafish embryo injections are carried out on the designed robotic micromanipulation system. The simulation and experimental results show that benefiting from the proposed model, the third-order speed trajectory provides the minimum cell deformation of 275.6$\mu$m at the puncture time of 0.21 s in comparison with the traditional integer models, and the degree of cell damage is improved by nearly 14% compared with the commonly used constant speed.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Fractional Viscoelastic Mechanical Model for Speed Optimization of Robotic Cell Microinjection
- Date Crossref
- 01/12/2024
- Éditeur
- Institute of Electrical and Electronics Engineers (IEEE)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Nanjing University of Information Science and Technology pays non établi dans la noticeUniversité ou école supérieure
-
Nanjing University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
-
Nanjing Institute of Technology pays non établi dans la noticeUniversité ou école supérieure
-
Nanjing University of Aeronautics and Astronautics pays non établi dans la noticeUniversité ou école supérieure
-
School of Automation pays non établi dans la noticeUniversité ou école supérieure
-
School of Mechanical Engineering pays non établi dans la noticeUniversité ou école supérieure
-
School of Innovation and Entrepreneurship Industrial Center pays non établi dans la noticeUniversité ou école supérieure
-
College of Mechanical and Electrical Engineering pays non établi dans la noticeUniversité ou école supérieure
Nanjing University of Information Science and Technology, Nanjing University of Science and Technology et Nanjing Institute of Technology, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.