Additional file 2 of Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
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Additional file 2: Table S1. Number of genes tested and Genomic inflation factor for each model and variant set. Table S2. Complete results of the genome-wide burden joint analysis, trans-pipeline meta-analysis and trans-ethnic meta-analysis on rare variants. Table S3. Best results of the genome-wide burden analysis on rare variants under a co-dominant and dominant model. Table S4. TLR7 homozygous and hemizygous variants (AF < 0.01). Table S5. Results of the genome-wide burden analysis on common and rare variants under a co-dominant model. Table S6. Results of the genome-wide burden analyses for the candidate genes identified by GWAS under co-dominant model. Table S7. Characteristics of patients and controls in the full sample and according to the inclusion in the Zhang Q. et al., Science 2020 paper. Table S8. Carriers of rare pLOF/bLOF variants in genes involved in type I IFN immunity to influenza virus. Table S9. Branchpoint variants identified by BPHunter and characteristics of the carriers. Table S10. Age and sex stratified analysis for the 15 type I IFN-related loci. Table S11. Enrichment analysis of rare variants, including missense and inframe variants, in genes involved in type I IFN immunity in the full cohort of 3269 cases and 1373 controls. Table S12. pLI and CoNeS distribution of the analyzed genes.
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interferon and immune responsesSARS-CoV-2 and COVID-19 Research