Williams_et_al_extended_data

Résumé fourni par la source

These extended data documents relate to the manuscript titled " Genome-wide association study of susceptibility to hospitalised respiratory infections", which has been submitted to Wellcome Open Research, and include the following files: · Supplementary materials and methods · Supplementary figures · Table S1: ICD-10 codes used to define the hospitalised respiratory infection phenotype. · Table S2: ICD-9 codes used to define the hospitalised respiratory infection phenotype in CHS and Partners Biobank. · Table S3: Summary statistics for the 56 sentinel variants from the discovery GWAS in UK Biobank. · Table S4: Availability of the 40 sentinel variants in the 11 follow-up cohorts. · Table S5: Results of the inverse variance-weighted fixed effects meta-analysis. · Table S6: Fine-mapping of the 56 association signals. · Table S7: Functional annotation of variants in the 95% credible sets. · Table S8: Association between variants in the 95% credible sets and gene expression across 48 tissues from GTEx (v7). · Table S9: Association between variants in the 95% credible sets and gene expression across three major human immune cell types from BLUEPRINT. · Table S10: Association between variants in the 95% credible sets and gene expression (cis-eQTLs) from eQTLGen. · Table S11: Colocalisation results from PICCOLO. · Table S12: Look-up of the sentinel variants in the 56 association signals in existing GWAS. · Table S13: Look-up of the sentinel variants in the 56 association signals in existing GWAS. · Table S14: Look-up of the sentinel variants in the 56 association signals in the COVID-19 Host Genetics Initiative meta-analysis results. Main materials and methods can be found in the main manuscript text.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.