Lesson from nature: Zataria multiflora nanostructured lipid carrier topical gel formulation against Candida-associated onychomycosis, a randomized double-blind placebo-controlled clinical trial
Rattachement africain : ir, gb, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The increasing resistance to onychomycosis treatment globally is a major concern as it results in treatment failures. This research aimed to investigate the effectiveness of incorporating nanostructured lipid carriers (NLCs) in a gel formulation for treating mild to moderate Candida-associated onychomycosis using Zataria multiflora (Zt) essential oils. The characteristics of Zataria multiflora-loaded nanostructured lipid carriers (Zt-NLCs) were validated using a carbopol gel (1 % w/w). In vitro tests were conducted using CLSI M60 standards to evaluate the susceptibility of ten commonly encountered dermatophyte species to antifungal agents. A clinical study was conducted involving 40 volunteers randomly assigned to two groups: one receiving the Zt-NLCs gel and the other receiving a placebo, using a double-blind, placebo-controlled design. The objective was to assess clinical manifestations and mycological findings after topical application for 2 and 4 weeks. The causative agents' species were identified using a PCR-RFLP method. The preparation of Zt-NLCs gel resulted in a uniform suspension of spherical nanoparticles with favourable characteristics and no cytotoxic effects. Zt-NLCs demonstrated significant inhibitory effects on fungal growth and effectively improved clinical and mycological criteria in comparison to the placebo group (p < 0.005), even after 2 weeks of treatment. The C. albicans complex was recognized as the predominant species isolated from the patients using PCR-RFLP. The administration of Zt-NLCs gel for two weeks showed significant efficacy in disease management, as reported by both dermatologists and mycologists and therefore shows its potential use as a treatment against Candidal onychomycosis.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Lesson from nature: Zataria multiflora nanostructured lipid carrier topical gel formulation against Candida-associated onychomycosis, a randomized double-blind placebo-controlled clinical trial
- Date Crossref
- 01/06/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Mazandaran University of Medical Sciences Invasive Fungi Research Center pays non établi dans la noticeUniversité ou école supérieure
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University of Huddersfield Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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University of Sussex pays non établi dans la noticeUniversité ou école supérieure
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Lupin Pharmaceuticals (United States) pays non établi dans la noticeEntreprise
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School of Medicine Department of Medical Mycology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Dermatology pays non établi dans la noticeUniversité ou école supérieure
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Lupin Research Inc pays non établi dans la noticeEntreprise
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School of Life Sciences Pharmaceutics Research Laboratory pays non établi dans la noticeUniversité ou école supérieure
Invasive Fungi Research Center — Mazandaran University of Medical Sciences, Department of Pharmacy — University of Huddersfield et University of Sussex, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.