Implications of Measles Inclusion by Commercial Syndromic Polymerase Chain Reaction Panels — United States, May 2022–April 2023
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Syndromic polymerase chain reaction (PCR) panels are used to test for pathogens that can cause rash illnesses, including measles. Rash illnesses have infectious and noninfectious causes, and approximately 5% of persons experience a rash 7-10 days after receipt of a measles, mumps, and rubella (MMR) vaccine. MMR vaccine includes live attenuated measles virus, which is detectable by PCR tests. No evidence exists of person-to-person transmission of measles vaccine virus, and illness does not typically result among immunocompetent persons. During September 2022-January 2023, the Tennessee Department of Health received two reports of measles detected by syndromic PCR panels. Both reports involved children (aged 1 and 6 years) without known risk factors for measles, who were evaluated for rash that occurred 11-13 days after routine MMR vaccination. After public health responses in Tennessee determined that both PCR panels had detected measles vaccine virus, six state health departments collaborated to assess the frequency and characteristics of persons receiving a positive measles PCR panel test result in the United States. Information was retrospectively collected from a commercial laboratory testing for measles in syndromic multiplex PCR panels. During May 2022-April 2023, among 1,548 syndromic PCR panels, 17 (1.1%) returned positive test results for measles virus. Among 14 persons who received a positive test result and for whom vaccination and case investigation information were available, all had received MMR vaccine a median of 12 days before specimen collection, and none had known risk factors for acquiring measles. All positive PCR results were attributed to detection of measles vaccine virus. Increased awareness among health care providers about potential measles detection by PCR after vaccination is needed. Any detection of measles virus by syndromic PCR testing should be immediately reported to public health agencies, which can use measles vaccination history and assessment of risk factors to determine the appropriate public health response. If a person recently received MMR vaccine and has no risk factors for acquiring measles, additional public health response is likely unnecessary.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Implications of Measles Inclusion by Commercial Syndromic Polymerase Chain Reaction Panels — United States, May 2022–April 2023
- Date Crossref
- 28/03/2024
- Éditeur
- Centers for Disease Control MMWR Office
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Tennessee Department of Health pays non établi dans la noticeOrganisme public
-
Epidemic Intelligence Service pays non établi dans la noticeOrganisme public
-
Florida Department of Health pays non établi dans la noticeOrganisme public
-
Illinois Department of Public Health pays non établi dans la noticeOrganisme public
-
NC Department of Health and Human Services pays non établi dans la noticeOrganisme public
-
Texas Department of State Health Services pays non établi dans la noticeOrganisme public
-
Virginia Department of Health pays non établi dans la noticeOrganisme public
-
National Center for Immunization and Respiratory Diseases pays non établi dans la noticeStructure de recherche
-
Vanderbilt University Medical Center pays non établi dans la noticeÉtablissement de santé
-
Career Epidemiology Field Officer Program pays non établi dans la noticeInstitution
-
North Carolina Department of Health and Human Services pays non établi dans la noticeInstitution
-
Division of Viral Diseases pays non établi dans la noticeInstitution
Tennessee Department of Health, Epidemic Intelligence Service et Florida Department of Health, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.