Auditory mismatch negativity in pre-manifest and manifest Huntington’s disease
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Le résumé fourni par la source
AIM: The aim of this study was to investigate the characteristics of the electrophysiological brain response elicited in a passive acoustic oddball paradigm, i.e. mismatch negativity (MMN), in patients with Huntington's disease (HD) in the premanifest (pHD) and manifest (mHD) phases. In this regard, we correlated the results of event-related potentials (ERP) with disease characteristics. METHODS: This was an observational cross-sectional MMN study. In addition to the MMN recording of the passive oddball task, all subjects with first-degree inheritance for HD underwent genetic testing for mutant HTT, the Huntington's Disease Rating Scale, the Total Functional Capacity Scale, the Problem Behaviors Assessment short form, and the Mini-Mental State Examination. RESULTS: We found that global field power (GFP) was reduced in the MMN time window in mHD patients compared to pHD and normal controls (NC). In the pHD group, MMN amplitude was only slightly and not significantly increased compared to mHD, while pHD patients showed increased theta coherence between trials compared to mHD. In the entire sample of HD gene carriers, the main MMN traits were not correlated with motor performance, cognitive impairment and functional disability. CONCLUSION: These results suggest an initial and subtle deterioration of pre-attentive mechanisms in the presymptomatic phase of HD, with an increasing phase shift in the MMN time frame. This result could indicate initial functional changes with a possible compensatory effect. SIGNIFICANCE: An initial and slight decrease in MMN associated with increased phase coherence in the corresponding EEG frequencies could indicate an early functional involvement of pre-attentive resources that could precede the clinical expression of HD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Auditory mismatch negativity in pre-manifest and manifest Huntington’s disease
- Date Crossref
- 01/06/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Bari Aldo Moro Department of Education pays non établi dans la noticeUniversité ou école supérieure
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Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari pays non établi dans la noticeÉtablissement de santé
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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Lieber Institute for Brain Development pays non établi dans la noticeOrganisation à but non lucratif
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Policlinico General Hospital Neurophysiopathology Unit pays non établi dans la noticeÉtablissement de santé
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Johns Hopkins School of Medicine Department of Psychiatry and Behavioral Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Education — University of Bari Aldo Moro, Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari et Johns Hopkins University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.