Regulatory role of miR ‐125a expression with respect to its target genes LIFR , ERBB2 and STAT3 in the pathogenesis of recurrent pregnancy losses
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Le résumé fourni par la source
OBJECTIVES: Studies have investigated miR-125a for its predictable role in recurrent pregnancy loss (RPL) cases to regulate many biological events required for the maintenance of pregnancy by regulating its confirmed target genes LIFR, ERBB2 and STAT3. METHODS: The present study included 40 cases of women with at least two RPLs in ≤20 weeks of gestation against 40 healthy multiparous women without a previous history of abortion. Expression analysis of ERBB2, LIFR, STAT3 and miR-125a was conducted by quantitative real-time PCR (qPCR). RESULTS: The expression of miR-125a was significantly lower in the plasma of RPL cases (P = 0.0001) and showed a significantly increased mean expression level in product of conception (2.56-fold, P < 0.0001). Among the target gene of miR-125a, ERBB2 and STAT3 gene expression level was significantly increased (2.58-fold, P = 0.04; 1.87-fold, P = 0.025), respectively in RPL cases while the LIFR gene revealed comparable expression (P = 0.64). Furthermore, expression analysis of ERBB2 gene with respect to its regulatory miR-125a cases depicted a significant association (P = 0.0005). Kaplan-Meier survival analysis revealed cases with low miR-125a expression had significantly shorter time to miscarriages, (log-rank P = 0.02). Also, decreased expression of miR-125a significantly conferred >2-fold increased risk for RPL (HR = 2.34: P < 0.05). CONCLUSION: The overall conclusion of the study was that altered miR-125a expression may cause deregulation in target genes LIFR, ERBB2 and STAT3 resulting in adverse consequence in the outcome of pregnancy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Regulatory role of <scp><i>miR</i></scp>‐125a expression with respect to its target genes <scp><i>LIFR</i></scp>, <scp><i>ERBB2</i></scp> and <scp><i>STAT3</i></scp> in the pathogenesis of recurrent pregnancy losses
- Date Crossref
- 25/03/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sher-i-Kashmir Institute of Medical Sciences Advanced Center for Human Genetics pays non établi dans la noticeUniversité ou école supérieure
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Jaipur National University pays non établi dans la noticeUniversité ou école supérieure
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University of Kashmir Department of Clinical Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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Advanced Center for Human Genetics Sher‐I‐Kashmir Institute of Medical Sciences (SKIMS) Srinagar Jammu and Kashmir India pays non établi dans la noticeStructure de recherche
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School of Life and Basic Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Obstetrics and Gynecology SKIMS Srinagar Jammu and Kashmir India pays non établi dans la noticeInstitution
Advanced Center for Human Genetics — Sher-i-Kashmir Institute of Medical Sciences, Jaipur National University et Department of Clinical Biochemistry — University of Kashmir, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.