A Histological Evaluation of the Efficiency of Using Periprosthetic Autologous Fat to Prevent Capsular Contracture Compared to Other Known Methods—An Experimental Study
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Le résumé fourni par la source
BACKGROUND: Capsular contracture remains a common complication in silicone breast implantation. The etiology, formation mechanisms, predisposing and favoring factors are still subjects of research. This study aims to demonstrate the effectiveness of using autologous fat introduced periprosthetically in preventing capsular contracture compared to other known methods: antibiotics and corticosteroids. METHODS: A cohort of 80 Wistar rats was included in the study, divided into four subgroups. All subjects received a silicone implant, implanted in a pocket created along the abdominal midline. The first subgroup served as the control group, with subjects having the implant placed without any treatment. For the second and third subgroups, the implants were treated with an antibiotic solution and intramuscular injections of dexamethasone, respectively. The subjects in the last subgroup received centrifuged autologous fat introduced periprosthetically. RESULTS: The subgroup with autologous fat exhibited a significantly smaller capsule thickness, which was poorly represented, with a smooth surface. The use of autologous fat for treating silicone prosthesis was linked with the lack of acute inflammation around the prosthetic site. CONCLUSIONS: Autologous fat helps to minimize the "non-self" reaction, which results in the development of a periprosthetic capsule consisting of mature collagen fibers interspersed with adipocytes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Histological Evaluation of the Efficiency of Using Periprosthetic Autologous Fat to Prevent Capsular Contracture Compared to Other Known Methods—An Experimental Study
- Date Crossref
- 21/03/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Grigore T. Popa University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi pays non établi dans la noticeÉtablissement de santé
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Advanced Neural Dynamics (United States) pays non établi dans la noticeEntreprise
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Carol Davila University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Clinical Emergency Hospital Bucharest pays non établi dans la noticeÉtablissement de santé
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Institutul Regional de Oncologie pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Department Plastic Surgery and Reconstructive pays non établi dans la noticeUniversité ou école supérieure
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“Sf. Spiridon” Emergency County Hospital Department of Plastic Surgery and Reconstructive Microsurgery pays non établi dans la noticeÉtablissement de santé
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“Grigore Alexandrescu” Clinical Emergency Hospital for Children Department of Plastic Reconstructive Surgery and Burns pays non établi dans la noticeÉtablissement de santé
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Surgery Clinic pays non établi dans la noticeÉtablissement de santé
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Second Oncological Clinic pays non établi dans la noticeÉtablissement de santé
Grigore T. Popa University of Medicine and Pharmacy, Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi et Advanced Neural Dynamics (United States), avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.