Prenatal exposure to polycyclic aromatic hydrocarbons and growth parameters
Rattachement africain : cz, sk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: It has long been known that airborne polycyclic aromatic hydrocarbons (PAHs) can negatively affect pregnancy and birth outcomes, such as birth weight, fetal development, and placental growth factors. However, similar studies yield divergent results. Our goal was to estimate the amount of monohydroxylated PAH (OH-PAH) metabolites in the urine of pregnant women/mothers and their newborns in relation to birth outcomes, such as placenta weight, Apgar 5', and the growth parameters of children up to the age of two. METHODS: Two cohorts of children born in 2013 and 2014 during the summer and winter seasons in the Czech Republic in the cities Karviná (N = 144) and České Budějovice (N = 198), which differ significantly in the level of air pollution, were studied. PAH exposure was assessed by the concentration of benzo[a]pyrene (B[a]P) in the air and the concentration of 11 OH-PAH metabolites in the urine of newborns and mothers. Growth parameters and birth outcomes were obtained from medical questionnaires after birth and from pediatric questionnaires during the following 24 months of the child's life. RESULTS: Concentrations of B[a]P were significantly higher in Karviná (p < 0.001). OH-PAH metabolites were significantly higher in the mothers' as well as in the newborns' urine in Karviná and during the winter season. Neonatal length was shorter in newborns in Karviná (p < 0.001), but this difference evened out during the next 3 to 24 months. Compared to České Budějovice, newborns in Karviná showed significantly lower weight gain between birth and three months after delivery. The OH-PAH metabolites in mothers' or newborns' urine did not affect birth weight. The presence of seven OH-PAH (top 25% of values of concentrations higher than the median) metabolites in the newborns' urine is associated with decreased length of newborn. Nine OH-PAH metabolites decreased placenta weight, which was the most significant, while seven OH-PAH metabolites decreased Apgar 5'. CONCLUSION: We have shown a possible connection between higher concentration of OH-PAH metabolites in newborns' urine and decreased length, head circumference, placenta weight, and Apgar 5', but not birth weight.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prenatal exposure to polycyclic aromatic hydrocarbons and growth parameters
- Date Crossref
- 15/03/2024
- Éditeur
- University of South Bohemia in Ceske Budejovice
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of South Bohemia in České Budějovice pays non établi dans la noticeUniversité ou école supérieure
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Czech Academy of Sciences pays non établi dans la noticeStructure de recherche
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Nemocnice České Budějovice pays non établi dans la noticeÉtablissement de santé
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Univerzitná Nemocnica Louisa Pasteura pays non établi dans la noticeÉtablissement de santé
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University of Chemistry and Technology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Experimental Medicine of the CAS pays non établi dans la noticeStructure de recherche
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deceased 2022-10-29 pays non établi dans la noticeInstitution
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Hospital Ceske Budejovice pays non établi dans la noticeÉtablissement de santé
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L. Pasteur University Hospital pays non établi dans la noticeUniversité ou école supérieure
University of South Bohemia in České Budějovice, Czech Academy of Sciences et Nemocnice České Budějovice, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.