P106: Single-cell and spatial transcriptomics integrated with bulk RNA-seq, uncovers differences in bidirectional tumor-macrophage crosstalk in IDHwt and IDHmut gliomas

Résumé fourni par la source

Gliomas are the most aggressive form of brain tumors. Despite notable advancements in targeted and immunotherapies, the standard of care for glioblastoma (GBM) has remained largely unchanged, predominantly due to the challenges posed by the intra-tumoral heterogeneity and its immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) residing in the TME are characterized by their pivotal roles in tumor progression, antitumor immunity and TME remodeling. However, knowledge of tumor-macrophage crosstalk in major categories of gliomas remains elusive.

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