Aller au contenu principal
Accès ouvert déclaré 2024 article

Characteristics of and risk factors for COVID-19 breakthrough infections in idiopathic inflammatory myopathies: results from the COVAD study

1Citations signalées, ce qui n’est pas une note de qualité
79Institutions déclarées
25Pays d’affiliation déclarés

Rattachement africain : br, in, au, gb, bd, lb, fr, bg, pl, se, mx, it, jp, de, tw, us, Nigéria, th, sa, my, Ghana, co, pk, Égypte, ch. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

OBJECTIVES: The objective of this study was to explore the prevalence, characteristics and risk factors of COVID-19 breakthrough infections (BIs) in idiopathic inflammatory myopathies (IIMs) using data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. METHODS: A validated patient self-reporting e-survey was circulated by the COVAD study group to collect data on COVID-19 infection and vaccination in 2022. BIs were defined as COVID-19 occurring ≥14 days after two vaccine doses. We compared BI characteristics and severity among patients with IIMs, patients with other autoimmune rheumatic and non-rheumatic diseases (AIRD, nrAID), and healthy controls (HCs). Multivariable Cox regression models were used to assess the risk factors for BI, severe BI ,and hospitalizations among patients with IIMs. RESULTS: Among the 9449 included responses, BIs occurred in 1447 respondents (15.3%). The median age was 44 years [interquartile range (IQR) 21], 77.4% were female, and 182 BIs (12.9%) occurred among the 1406 patients with IIMs. Multivariable Cox regression among the data for patients with IIMs showed increasing age to be a protective factor for BIs [hazard ratio (HR) = 0.98, 95% CI = 0.97-0.99], and HCQ and SSZ use were risk factors (HR = 1.81, 95% CI = 1.24-2.64, and HR = 3.79, 95% CI = 1.69-8.42, respectively). Glucocorticoid use was a risk factor for a severe BI (HR = 3.61, 95% CI = 1.09-11.8). Non-white ethnicity (HR = 2.61, 95% CI = 1.03-6.59) was a risk factor for hospitalization. Compared with other groups, patients with IIMs required more supplemental oxygen therapy (IIMs = 6.0% vs AIRDs = 1.8%, nrAIDs = 2.2% and HCs = 0.9%), intensive care unit admission (IIMs = 2.2% vs AIRDs = 0.6%, nrAIDs and HCs = 0%), advanced treatment with antiviral or monoclonal antibodies (IIMs = 34.1% vs AIRDs = 25.8%, nrAIDs = 14.6% and HCs = 12.8%) and had more hospitalization (IIMs = 7.7% vs AIRDs = 4.6%, nrAIDs = 1.1% and HCs = 1.5%). CONCLUSION: Patients with IIMs are susceptible to severe COVID-19 BIs. Age and immunosuppressive treatments were related to the risk of BIs.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Characteristics of and risk factors for COVID-19 breakthrough infections in idiopathic inflammatory myopathies: results from the COVAD study
Date Crossref
02/03/2024
Éditeur
Oxford University Press (OUP)
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

Universidade PotiguarSanjay Gandhi Post Graduate Institute of Medical SciencesMaulana Azad Medical CollegeThe Royal Melbourne HospitalThe University of MelbourneWalter and Eliza Hall Institute of Medical ResearchB. J. Medical College & Sassoon HospitalSouthport and Ormskirk Hospital NHS TrustKing's College LondonKing's College HospitalMymensingh Medical College HospitalUniversity of LeedsLeeds Teaching Hospitals NHS TrustNIHR Leeds Musculoskeletal Biomedical Research UnitUniversidade de São PauloSaint Joseph UniversityHôtel-Dieu de ParisHôtel-Dieu de FranceSofia University "St. Kliment Ohridski"Pomeranian Medical UniversityKing Edward Memorial Hospital and Seth G.S. Medical CollegeKarolinska University HospitalÖrebro UniversityKarolinska InstitutetMexican Social Security InstituteCentro Médico Nacional La RazaUniversity of PaviaNippon Medical SchoolFriedrich-Alexander-Universität Erlangen-NürnbergUniversitätsklinikum ErlangenTaichung Veterans General HospitalMayo Clinic in ArizonaMahatma Gandhi Mission Medical College and HospitalUniversity of VirginiaNorth Bristol NHS TrustUniversity of BristolArthritis UKUniversity College LondonAll India Institute of Medical Sciences BhubaneswarAll India Institute of Medical Sciences GuwahatiInstituto Nacional de Enfermedades RespiratoriasUniversidad de GuadalajaraHospital Civil de GuadalajaraHospital Universitario Dr José Eleuterio GonzalezInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránUniversity of Nigeria Teaching HospitalSiriraj HospitalMahidol UniversityMemorial HospitalUniversity Hospital St. Ivan RilskiRiyadh Armed Forces HospitalChildren's Specialized HospitalKing Faisal Specialist Hospital & Research CentreInstitute for Rheumatic Diseases (Japan)University Kebangsaan Malaysia Medical CentreNational University of MalaysiaEnam Medical College & HospitalDhaka Medical College and HospitalUniversity of GhanaPontificia Universidad JaverianaUniversidad del NorteManchester Academic Health Science CentreSalford Royal NHS Foundation TrustUniversity of ManchesterFoundation University Medical CollegeCairo UniversityIllinois CollegePeoria campus of the University of Illinois SystemUniversity of ZurichUniversity Hospital ZurichHospital de EspecialidadesNational Institute for Health and Care ResearchManchester University NHS Foundation TrustSalford Royal HospitalNIHR Manchester Biomedical Research CentreUniversity of PittsburghSandwell & West Birmingham Hospitals NHS TrustThe Royal Wolverhampton NHS TrustWolverhampton Hospital

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Inflammatory Myopathies and DermatomyositisSARS-CoV-2 and COVID-19 ResearchRheumatoid Arthritis Research and Therapies

BNTIC News n’est pas le producteur de ces données. Les publications sont interrogées à la demande dans Crossref, OpenAIRE, DOAJ, Europe PMC, HAL, DataCite, AfricArXiv, ROR et la Banque mondiale, sans clé d’accès. OpenAlex reste optionnel. Aucun service payant n’est nécessaire et aucune donnée externe n’est enregistrée en base. Consulter les sources et leurs limites.