Platelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients
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Le résumé fourni par la source
Abstract Objectives The cardiovascular mortality risk is greatly increased in patients with chronic kidney disease (CKD), especially in dialysis patients, due to atherosclerosis. Platelet activating factor acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes platelet activating factor (PAF). Valvular calcifications and PAF-AH are associated with atherosclerosis. However, little is known about the status of PAF-AH activity and valvular calcification in dialysis patients. Therefore, the aim of this study was to investigate the status of these parameters in CKD patients. Methods This study included 92 chronic renal failure (CRF) (dialysis group), and 86 CKD patients (non-dialysis group). Echocardiography was performed to assess valvular calcification. Results There was no significant difference between the dialysis and CKD groups in terms of PAF-AH activities. However, when comparisons were stratified according to the presence of valve calcification, higher PAF-AH activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were evident in patients with calcification compared to those without. Additionally, the CRF group also exhibited elevated PAF-AH and NT-proBNP levels. While elevated NT-proBNP persisted in the CKD group, in contrast, changes in PAF-AH were not significant. Conclusions The results of this study suggest that high PAF-AH and NT-proBNP levels are associated with valvular calcification in dialysis patients. Both biomarkers may be used as a risk factor for calcification. Furthermore, inhibition of PAF-AH activity may be a treatment target to reduce calcification.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Platelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients
- Date Crossref
- 01/03/2024
- Éditeur
- Walter de Gruyter GmbH
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sivas Cumhuriyet Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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Sağlık Bilimleri Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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Ankara Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
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University of Health Sciences Antigua Department of Medical Biochemistry pays non établi dans la noticeUniversité ou école supérieure
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Erciyes University pays non établi dans la noticeUniversité ou école supérieure
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Giresun University pays non établi dans la noticeUniversité ou école supérieure
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Lokman Hekim Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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Department of Medical Biochemistry pays non établi dans la noticeInstitution
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Department of Cardiology pays non établi dans la noticeInstitution
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Department of Internal Medicine pays non établi dans la noticeInstitution
Sivas Cumhuriyet Üniversitesi, Sağlık Bilimleri Üniversitesi et Ankara Eğitim ve Araştırma Hastanesi, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.