Green synthesis and anti-tumor activity of curcumin @ ZnO/CuO nanoparticles

Le résumé fourni par la source

Both zinc oxide and copper oxide nanoparticles are promising biologically active materials. Green synthesis approach was used to prepare mixed ZnO/CuO nanoparticles loaded with curcumin extract. The isolated mixed oxides loaded with curcumin (curcumin @ ZnO/CuO) was characterized by UV–visible spectra, FTIR spectra, X-ray powder diffractions (XRD),Transmittance electron microscope (TEM), Energy dispersive x-ray (EDX) and x-ray photoelectron spectroscopy (XPS) spectra. X-ray powder diffractions indicated that ZnO has wurtzite structure and CuO crystallizes in a monoclinic system. XPS confirmed the existence of both CuO and ZnO nanoparticles. TEM results indicated the formation of quantum dots of curcumin @ ZnO/CuO with size in the range 6–10 nm. The optical band gaps of curcumin @ ZnO/CuO were determined and found to be 3.4 and 4.05 eV, which are higher than the bulk. The effects of curcumin @ ZnO/CuO on hepatocellular (HEPG-2) and colorectal (HCT-116) carcinoma were estimated by cell viability, cell cycle and anti-apoptotic factors (caspase-3/7, topoisomerase 2beta and annexin). Strong cytotoxicity activity and apoptosis of tumor cells were observed for curcumin @ ZnO/CuO. The cytotoxicity of the current compounds showed higher activity in comparison with other compounds that were previously studied.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.