Restricted diffusion characteristics in oscillating gradient spin echo with mesoscopic phantom

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) for the sine and cosine waveforms using the capillary phantom (6, 12, 25, 50, and 100 μm and free water) with a 9.4-T experimental magnetic resonance imaging system and a solenoid coil. We evaluated the axial and radial diffusivity (AD, RD) of each structure size. The output current of the MPG was assessed with an oscilloscope and analyzed with the gradient modulation power spectra by fast Fourier transform. In sine, the sidelobe spectrum was enhanced with increasing frequency, and the central spectrum slightly increased. The difference in RD was detected at 6 and 12 μm; however, it did not depend on the structure scale at 50 or 100 μm and free water. In cosine, the diffusion spectrum was enhanced, whereas the central spectrum decreased with increasing frequency. Both AD and RD in cosine had a frequency dependence, and AD and RD increased with a higher frequency regardless of structure size. AD and RD in either sine or cosine had no evident b-value dependence. We evaluated the OGSE-restricted diffusion characteristics. The measurements obtained diffusion information similar to the pulsed gradient spin echo. Hence, the cosine measurements indicated that a higher frequency could capture faster diffusion within the diffusion phenomena.

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