Molecular epidemiology of canine parvovirus type 2 in Sicily, southern Italy: A geographical island, an epidemiological continuum
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Since it emerged as a major dog pathogen, canine parvovirus type 2 (CPV-2) has featured a remarkable genetic and phenotypic heterogeneity, whose biological, epidemiological, and clinical impact is still debated. The continuous monitoring of this pathogen is thus of pivotal importance. In the present study, the molecular epidemiology of CPV-2 in Sicily, southern Italy, has been updated by analysing 215 nearly complete sequences of the capsid protein VP2, obtained from rectal swabs/faeces or tissue samples collected between 2019 and 2022 from 346 dogs with suspected infectious gastrointestinal disease. The presence of the original CPV-2 type (4%) and CPV-2a (9%), CPV-2b (18%), or CPV-2c (69%) variants was documented. Over the years, we observed a decrease in the frequency of CPV-2a/-2b and a rapid increase of CPV-2c frequency, with a progressive replacement of the European lineage of CPV-2c by the Asian lineage. The observed scenario, besides confirming epidemiological relevance of CPV-2, highlights the occurrence of antigenic variant shifts over time, with a trend toward the replacement of CPV-2a, CPV-2b, and the European lineage of CPV-2c by the emerging Asian CPV-2c lineage. The comparison with other Italian and international sequences suggests the occurrence of viral exchange with other Italian regions and different countries, although the directionality of such viral flows could not be often established with confidence. In several instances, potential CPV-2 introductions led to epidemiological dead ends. However, major, long-lasting clades were also identified, supporting successful infection establishment, local spreading, and evolution. These results, besides demonstrating the need for implementing more effective control measures to prevent viral introductions and minimize circulation, stress the relevance of routine monitoring activities as the only tool to effectively understand CPV-2 epidemiology and evolution, and develop adequate countermeasures.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Molecular epidemiology of canine parvovirus type 2 in Sicily, southern Italy: A geographical island, an epidemiological continuum
- Date Crossref
- 01/02/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Messina Department of Veterinary Science pays non établi dans la noticeUniversité ou école supérieure
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Istituto Zooprofilattico Sperimentale Della Sicilia pays non établi dans la noticeStructure de recherche
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University of Padua Department of Animal Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Milan pays non établi dans la noticeUniversité ou école supérieure
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Centre for Multidisciplinary Research in Health Science pays non établi dans la noticeStructure de recherche
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University of Bari Aldo Moro Department of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Coordinate Research Centre EpiSoMI (Epidemiology and Molecular Surveillance of Infections) pays non établi dans la noticeStructure de recherche
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Department of Pathophysiology and Transplantation pays non établi dans la noticeInstitution
Department of Veterinary Science — University of Messina, Istituto Zooprofilattico Sperimentale Della Sicilia et Department of Animal Medicine — University of Padua, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.