Effects of combined exposure of manganese and iron on serum inflammatory factor levels among workers

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Abstract Background Manganese (Mn) and iron (Fe) are commonly used in the manufacturing of ferroalloys and the ore mining industry. Long-term occupational exposure to Mn and Fe will cause adverse health effects to workers. Methods 108 Mn workers in 4 Mn operational factories in Guangxi were selected for the Mn exposure groups, stratified by job type, gender, age, and working age; 92 non-Mn workers from the sugar factory, indoor office, and non-contact metal smelting were in the control group. Inductively coupled plasma-mass spectrometry (ICP-MS) was used to determine the Mn and Fe concentration in the working environment. Graphite furnace-atomic absorption spectroscopy (GFAAS) was used to determine the blood Mn concentration of workers. Serum inflammatory factor concentrations (TNF-α, PGE2, IL-1β, IL-2, IL-6, IL-8 ) were monitored by ELISA. Results The average geometric concentrations of Mn and Fe in the working air were 0.006 mg/m3 and 0.0234 mg/m3, respectively. The blood Mn concentration and positive rate of clinical neurological symptoms in the Mn exposure group was higher than in the control group. Blood Mn concentration was positively correlated with various serum inflammatory factors. The concentrations of various serum inflammatory factors were positively correlated with each other. Conclusions Our results show that low levels of Mn exposure increase blood Mn concentrations and the rate of complaints of neurological symptoms in workers, as well as led to an increase in serum levels, suggesting that low levels of Mn exposure promote increased serum inflammatory response.

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