Associations of Abdominal Muscle Density and Area and Incident Cardiovascular Disease, Coronary Heart Disease, and Stroke: The Multi‐Ethnic Study of Atherosclerosis
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Le résumé fourni par la source
Background Muscle density is inversely associated with all‐cause mortality, but associations with cardiovascular disease (CVD) risk are not well understood. This study evaluated the association between muscle density and muscle area and incident total CVD, coronary heart disease (CHD), and stroke in diverse men and women. Methods and Results Adult participants (N=1869) in the Multi‐Ethnic Study of Atherosclerosis Ancillary Body Composition Study underwent computer tomography scans of the L2‐L4 region of the abdomen. Muscle was quantified by density (Hounsfield units) and area in cm 2 . Sex‐stratified Cox proportional hazard models assessed associations between incident total CVD, incident CHD, and incident stroke across sex‐specific percentiles of muscle area and density, which were entered simultaneously into the model. Mean age for men and women at baseline were 64.1 and 65.1 years, respectively, and median follow‐up time was 10.3 years. For men, associations between muscle density and incident CVD were inverse but not significant in fully adjusted models ( P trend=0.15). However, there was an inverse association between density and CHD ( P trend=0.02; HR, 0.26 for 95th versus 10th percentile), and no association with stroke ( P trend=0.78). Conversely, for men, there was a strong positive association between muscle area and incident CVD (HR, 4.19 for 95th versus 10th percentile; P trend<0.001). Associations were stronger for CHD (HR, 6.18 for 95th versus 10th percentile; P trend<0.001), and null for stroke ( P trend=0.67). Associations for women were mostly null. Conclusions For men, abdominal muscle density is associated with lower CHD risk, whereas greater muscle area is associated with markedly increased risk of CHD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Associations of Abdominal Muscle Density and Area and Incident Cardiovascular Disease, Coronary Heart Disease, and Stroke: The Multi‐Ethnic Study of Atherosclerosis
- Date Crossref
- 20/02/2024
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California San Diego Department of Family Medicine & pays non établi dans la noticeUniversité ou école supérieure
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Human Longevity (United States) pays non établi dans la noticeEntreprise
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University of Washington Department of Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Pittsburg State University pays non établi dans la noticeUniversité ou école supérieure
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University of Idaho Department of Movement Sciences pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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Herbert Wertheim School of Public Health and Human Longevity Science John Bellettiere https://orcid.org/0000-0002-7167-3048 pays non établi dans la noticeUniversité ou école supérieure
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Department of Epidemiology University of Pittsburg PA USA Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Department of Medicine Johns Hopkins School of Medicine Baltimore MD USA Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Family Medicine & — University of California San Diego, Human Longevity (United States) et Department of Biostatistics — University of Washington, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.