Serum binding folate receptor autoantibodies lower in autistic boys and positively-correlated with folate
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Le résumé fourni par la source
Folate receptor autoantibody (FRAA) has caught increasing attention since its discovery in biological fluids of patients with autism spectrum disorder (ASD), but quantification and understanding of its function are still in their infancy. In this study, we aimed to quantify serum binding-FRAA and explore its relation with serum folate, vitamin B12 (VB12) and ferritin. We quantitated serum binding-FRAA in 132 ASD children and 132 typically-developing (TD) children, as well as serum levels of folate, VB12 and ferritin. The results showed that serum binding-FRAA in the ASD group was significantly lower than that in the TD group (p < 0.0001). Further analysis showed that the difference between these two groups was attributed to boys in each group, not girls. There was no statistically significant difference in folate levels between the ASD and TD groups (p > 0.05). However, there was significant difference in boys between these two groups, not girls. Additionally, the combination of nitrite and binding-FRAA showed potential diagnostic value in patients with ASD (AUC > 0.7). Moreover, in the ASD group, the level of folate was consistent with that of binding-FRAA, whereas in the TD group, the binding-FRAA level was high when the folate level was low. Altogether, these differences revealed that the low serum FRAA in autistic children was mediated by multiple factors, which deserves more comprehensive investigation with larger population and mechanistic studies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Serum binding folate receptor autoantibodies lower in autistic boys and positively-correlated with folate
- Date Crossref
- 01/03/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hubei Provincial Women and Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Hubei University of Technology Center for Redox Biology & Precision Medicine of Hubei Province pays non établi dans la noticeUniversité ou école supérieure
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University of Maryland Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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North Carolina State University Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Peking Union Medical College Hospital Medical Science Research Center pays non établi dans la noticeÉtablissement de santé
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Peking University Neuroscience Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Hubei Maternity and Child Health Care Hospital Department of Child Health Care pays non établi dans la noticeÉtablissement de santé
Hubei Provincial Women and Children's Hospital, Center for Redox Biology & Precision Medicine of Hubei Province — Hubei University of Technology et Department of Chemistry — University of Maryland, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.