Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomised Controlled Trials
Rattachement africain : es. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
We conducted this systematic review with the objective to understand the efficacy and safety of proton pump inhibitors [PPIs] in the pediatric population. We have used PubMed to identify randomized controlled trials [RCTs] published between 1st June 2010 and 30th June 2023, in patients from birth to 18 years old, with gastroesophageal reflux disease [GERD], who received treatment with any PPI. The literature yielded 76 articles and 13 met inclusion criteria. For infants, PPIs were equal to placebo in reducing GERD symptoms in 4 articles. In 1, the number of GER episodes and esophageal acid exposure were lower in infants who received PPIs and left lateral position, but there was no significant improvement in symptoms. In another publication, the combination of PPIs and feeding modifications [FM] was not more effective than PPIs alone. For children and adolescents, PPIs were effective in improving symptoms and achieving mucosal and histological healing, which was subsequently maintained. To conclude, PPIs are not effective to reduce symptoms related to GERD in infants, but are effective in older children, along with histological remission. Generally, PPIs are well tolerated, but it is important to not forget the possible adverse events [AE], especially if they are used for a long time.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomised Controlled Trials
- Date Crossref
- 31/01/2024
- Éditeur
- MDPI AG
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade da Coruña pays non établi dans la noticeUniversité ou école supérieure
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Hepatology and Nutrition Unit . Department of Pediatrics A Coruña University Hospital. Area Sanitaria A Coruña-Cee . Spain Pediatric Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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Hepatology and Nutrition Unit. Department of Pediatrics A Coruña University Hospital. Area Sanitaria A Coruña-Cee. Spain Pediatric Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
Universidade da Coruña, Pediatric Gastroenterology — Hepatology and Nutrition Unit . Department of Pediatrics A Coruña University Hospital. Area Sanitaria A Coruña-Cee . Spain et Pediatric Gastroenterology — Hepatology and Nutrition Unit. Department of Pediatrics A Coruña University Hospital. Area Sanitaria A Coruña-Cee. Spain.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.