Functional and Morphological Disorders of Taste and Olfaction in COVID-19-Patients
Rattachement africain : gr, at, de. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Objectives: To test the prevalence and evolution of acute olfactory and gustatory functional impairment and of their morphologic correlates in COVID-19 patients who require hospitalization due to COVID-19-related respiratory conditions. Key-words: COVID-19, taste, olfaction, electrogustometry, contact endoscopy Design: Electrogustometric (EGM) - thresholds at the tongue area supplied by the chorda tympani, at the soft palate and at the vallate papillae area were recorded bilaterally. Olfaction was examined by Sniffin’ sticks. The patients’ nasal and oral mucosa (fungiform papillae, fpap) were examined by contact endoscopy. Setting: Tertiary referral medical centre. Patients: 53 consecutive hospitalized patients (23 males, 30 females, age 42,54 ± 10, 95 yrs) with RT-PCR-confirmed COVID-19 diagnosis were included. Patients have been examined twice: just after hospital discharge and 4-6 weeks later. Main outcome measures: EGM-thresholds and taste strips, Schniffin-Sticks, Contact-Endoscopyesults: EGM-thresholds in patients were significantly higher at both instances than those of healthy subjects. EGM-thresholds at the second measurement were significantly lower than those at the first measurement. Accordingly, patient-reported gustatory outcomes were improved at the second measurement. The same pattern has been found using Sniffin’ sticks. Significant alterations in form and vascularization of fPap have been detected in patients, especially at the first instance. Conclusions: COVID-19 affects both gustatory and olfactory functions. It also affects in parallel the structure and vascularization of both nasal and oral mucosa, although the nasal mucosa to a much less, non-significant, extent. Our findings suggest that COVID-19 may cause a mild to profound neuropathy of multiple cranial nerves.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Functional and Morphological Disorders of Taste and Olfaction in COVID-19-Patients
- Date Crossref
- 31/01/2024
- Éditeur
- Wiley
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
G. Papanikolaou General Hospital pays non établi dans la noticeÉtablissement de santé
-
Medical University of Graz pays non établi dans la noticeUniversité ou école supérieure
-
Veria General Hospital pays non établi dans la noticeÉtablissement de santé
-
Johannes Gutenberg University Mainz pays non établi dans la noticeUniversité ou école supérieure
-
University Medical Center of the Johannes Gutenberg University Mainz pays non établi dans la noticeÉtablissement de santé
-
General Hospital of Thessaloniki G Papanikolaou pays non établi dans la noticeÉtablissement de santé
-
General Hospital Veria pays non établi dans la noticeÉtablissement de santé
-
Johannes Gutenberg University Hospital Mainz pays non établi dans la noticeUniversité ou école supérieure
G. Papanikolaou General Hospital, Medical University of Graz et Veria General Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.